癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Nectin-4
- 产品详情
- 实验流程
| Primary Accession | Q8R007 |
|---|---|
| Species | Mouse |
| Sequence | Gly31-Ser347 |
| Purity | > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC |
| Endotoxin Level | Less than 1EU per µg by the LAL method. |
| Biological Activity | Immobilized Nectin-4, His, Mouse (Cat.No.: Z03826) at 2 µg/ml on the plate can bind Human Nectin-1, hFc Tag. |
| Expression System | HEK293 |
| Theoretical Molecular Weight | 35.4 kDa |
| Formulation | Lyophilized from a 0.22 µm filtered solution in PBS, pH 7.4. |
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 µg/ml is recommended. Dissolve the lyophilized protein in distilled water. |
| Storage & Stability | Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles. |
| Gene ID | 71740 |
|---|---|
| Other Names | Nectin-4, Ig superfamily receptor LNIR, Nectin cell adhesion molecule 4, Poliovirus receptor-related protein 4, Nectin4 {ECO:0000250|UniProtKB:Q96NY8}, Lnir, Prr4, Pvrl4 |
| Target Background | Nectin-4 is a tumor-associated antigen. It is probably involved in cell adhesion through trans-homophilic and -heterophilic interactions. Nectin-4 is overexpressed in urothelial carcinoma and several other malignancies. It is a promising target for antibody-drug conjugates (ADCs). |
| Name | Nectin4 {ECO:0000250|UniProtKB:Q96NY8} |
|---|---|
| Synonyms | Lnir, Prr4, Pvrl4 |
| Function | Seems to be involved in cell adhesion through trans- homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Plays a role in the senescence- associated cell size enlargement via SFK/PI3K/Rac1 and thus promotes senescent cell survival. Also participates in the innate immune response by acting as a ligand for the receptor TIGIT to inhibit NK- cell activity. |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q96NY8}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q96NY8} Cell junction, adherens junction {ECO:0000250|UniProtKB:Q96NY8} Note=Colocalizes with AFDN at cadherin-based adherens junctions {ECO:0000250|UniProtKB:Q96NY8} |
| Tissue Location | Expressed in brain, lung, testis and embryo. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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