癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
IL-6
- 产品详情
- 实验流程
| Primary Accession | P26892 |
|---|---|
| Species | Bovine |
| Sequence | Gly30-Lys208 |
| Purity | ≥ 95% as analyzed by SDS-PAGE |
| Endotoxin Level | < 0.2 EU/ µg of protein by gel clotting method |
| Expression System | P. pastoris |
| Theoretical Molecular Weight | 20.7 kDa |
| Formulation | Lyophilized from a 0.2 µm filtered solution in PBS, pH 7.4 |
| Reconstitution | Before opening, centrifuge the vial briefly to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH2O up to 100 µg/ml |
| Storage & Stability | Upon receiving, this product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable up to 1 week at 4 °C or up to 3 months at -20 °C or below. Avoid repeated freeze-thaw cycles. |
| Gene ID | 280826 |
|---|---|
| Other Names | Interleukin-6, IL-6, IL6 |
| Target Background | Interleukin-6 (IL-6), also known as BSF-2, CDF and IFNB2, is a pleiotropic cytokine. IL-6 participates in both pro-inflammatory and anti-inflammatory responses. IL-6 is produced mainly by T cells, macrophages and muscle cells. It stimulates B cell differentiation and antibody production, and cell differentiation. |
| Name | IL6 |
|---|---|
| Function | Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway. The interaction with the membrane- bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells. |
| Cellular Location | Secreted {ECO:0000250|UniProtKB:P05231}. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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