FOLR1

Product Information
Primary Accession	P35846
Species	Mouse
Sequence	Thr25-Ser232
Purity	> 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC
Endotoxin Level	Less than 1EU per µg by the LAL method.
Expression System	HEK293
Theoretical Molecular Weight	25.36 kDa
Formulation	Lyophilized from a 0.22 µm filtered solution in PBS, pH 7.4 .
Reconstitution	It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH₂O more than 100 µg/ml.
Storage & Stability	Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Additional Information
Gene ID	14275
Other Names	Folate receptor alpha, FR-alpha, Folate receptor 1, Folate-binding protein 1, Folr1, Fbp1, Folbp1
Target Background	Folate Receptor 1 (FOLR1), also known as Folate Receptor alpha and Folate Binding Protein (FBP), is a 37 - 42 kDa protein that mediates the cellular uptake of folic acid and reduced folates. Dietary folates are required for many key metabolic processes including nucleotide and methionine synthesis, the interconversion of glycine and serine, and histidine breakdown. FOLR1 binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH.

Protein Information
Name	Folr1
Synonyms	Fbp1, Folbp1
Function	Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells (PubMed:1894617). Has high affinity for folate and folic acid analogs at neutral pH (By similarity). Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release (By similarity). Required for normal embryonic development and normal cell proliferation (PubMed:10508523, PubMed:12854656, PubMed:15259034, PubMed:17286298). Required for renal folate reabsorption (PubMed:15703271).
Cellular Location	Cell membrane {ECO:0000250\|UniProtKB:P15328}; Lipid-anchor, GPI-anchor {ECO:0000250\|UniProtKB:P15328}. Apical cell membrane {ECO:0000250\|UniProtKB:P15328}; Lipid-anchor, GPI-anchor {ECO:0000250\|UniProtKB:P15328}. Basolateral cell membrane {ECO:0000250\|UniProtKB:P15328}; Lipid-anchor, GPI-like-anchor {ECO:0000250\|UniProtKB:P15328}. Secreted {ECO:0000250\|UniProtKB:P15328}. Cytoplasmic vesicle {ECO:0000250\|UniProtKB:P15328}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250\|UniProtKB:P15328}. Endosome {ECO:0000250\|UniProtKB:P15328}. Note=Endocytosed into cytoplasmic vesicles and then recycled to the cell membrane {ECO:0000250\|UniProtKB:P15328}
Tissue Location	Detected in kidney proximal tubules (at protein level).