癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Her3/ErbB3
- 产品详情
- 实验流程
| Primary Accession | Q61526 |
|---|---|
| Species | Mouse |
| Sequence | Ser20-His641 |
| Purity | > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC |
| Endotoxin Level | Less than 1EU per µg by the LAL method. |
| Biological Activity | Immobilized Her3/ErbB3, His, Mouse (Cat.No.: Z03910) at 2 µg/ml (100 µl/Well) on the plate can bind Human NRG1 Beta 1, hFc Tag |
| Expression System | HEK293 |
| Theoretical Molecular Weight | 69.59 kDa |
| Formulation | Lyophilized from a 0.22 µm filtered solution in PBS, pH 7.4. |
| Reconstitution | It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH2O more than 100 µg/ml. |
| Storage & Stability | Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles. -80°C for 3 months after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
| Gene ID | 13867 |
|---|---|
| Other Names | Receptor tyrosine-protein kinase erbB-3, 2.7.10.1, Glial growth factor receptor, Proto-oncogene-like protein c-ErbB-3, Erbb3 |
| Target Background | Her3, also called ErbB3, is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors.Her3 is expressed in keratinocytes, melanocytes, skeletal muscle cells, embryonic myoblasts and Schwann cells. Monomeric Her3 serves as a low affinity receptor for the heregulins (HRG). |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Erbb3 |
|---|---|
| Function | Tyrosine kinase receptor that, despite substitutions of key catalytic residues in the kinase domain, retains residual catalytic activity enabling autophosphorylation. Functions primarily as a heterodimer, preferentially partnering with ERBB2/HER2, which phosphorylates ERBB3 on specific tyrosine residues and provides the kinase activity required for downstream signaling. Binds neuregulins NRG1 and NRG2 through its extracellular domain, which induces conformational change from a tethered autoinhibited state to an extended conformation competent for dimerization. Upon heterodimerization and trans-phosphorylation, acts as the most efficient activator of the PI3K/AKT pathway within the ErbB family. Also activates the RAS/MAPK/ERK cascade to promote cell proliferation (By similarity). Plays an essential role in cardiac development; required for normal formation of the endocardial cushion and ventricular trabeculation during embryogenesis (PubMed:9362461). Critical for peripheral nervous system development, where neuregulin- 1/ERBB3 signaling drives Schwann cell survival, proliferation, and differentiation, and is required for axonal myelination (PubMed:9338783). Involved in epithelial morphogenesis and mammary gland development (PubMed:19019207). Also involved in the regulation of myeloid cell differentiation. Participates in a regulatory feedback loop whereby pathway activation induces transcriptional up-regulation of ERBB3 expression. Participates in vesicular sorting by stabilizing the ARF6-GGA3-RABEP1 endosomal sorting complex, to promote early recycling of TFRC and ITGB1. May also be activated by additional ligands including CSPG5 and EGFL6; the latter triggers assembly of an ERBB2/ERBB3/ITGB3 signaling complex leading to ERK phosphorylation and cell proliferation (By similarity). |
| Cellular Location | Membrane; Single-pass type I membrane protein |
| Tissue Location | In the muscle, expression localizes to the synaptic sites of muscle fibers |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
终于等到您。ABCEPTA（百远生物）抗体产品。
点击下方“我要评价 ”按钮提交您的反馈信息，您的反馈和评价是我们最宝贵的财富之一,
我们将在1-3个工作日内处理您的反馈信息。
如有疑问，联系：0512-88856768 tech-china@abcepta.com.
