癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Her3/ErbB3
- 产品详情
- 实验流程
| Primary Accession | Q61526 |
|---|---|
| Species | Mouse |
| Sequence | Ser20-His641 |
| Purity | > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC |
| Endotoxin Level | Less than 1EU per µg by the LAL method. |
| Biological Activity | Immobilized Her3/ErbB3, His, Mouse (Cat.No.: Z03910) at 2 µg/ml (100 µl/Well) on the plate can bind Human NRG1 Beta 1, hFc Tag |
| Expression System | HEK293 |
| Theoretical Molecular Weight | 69.59 kDa |
| Formulation | Lyophilized from a 0.22 µm filtered solution in PBS, pH 7.4. |
| Reconstitution | It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH2O more than 100 µg/ml. |
| Storage & Stability | Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles. -80°C for 3 months after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
| Gene ID | 13867 |
|---|---|
| Other Names | Receptor tyrosine-protein kinase erbB-3, 2.7.10.1, Glial growth factor receptor, Proto-oncogene-like protein c-ErbB-3, Erbb3 |
| Target Background | Her3, also called ErbB3, is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors.Her3 is expressed in keratinocytes, melanocytes, skeletal muscle cells, embryonic myoblasts and Schwann cells. Monomeric Her3 serves as a low affinity receptor for the heregulins (HRG). |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Erbb3 |
|---|---|
| Function | Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation. |
| Cellular Location | Membrane; Single-pass type I membrane protein |
| Tissue Location | In the muscle, expression localizes to the synaptic sites of muscle fibers |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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