癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
DLL4
- 产品详情
- 实验流程
| Primary Accession | Q9NR61 |
|---|---|
| Species | Human |
| Sequence | Ser27-Pro524 |
| Purity | > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC |
| Endotoxin Level | Less than 1EU per µg by the LAL method. |
| Biological Activity | Immobilized DLL4[Biotin], His, Human (Cat.No.: Z03956) at 2 µg/ml (100 µl/Well) on the streptavidin precoated plate can bind Anti-DLL4 Antibody, hFc Tag |
| Expression System | HEK293 |
| Theoretical Molecular Weight | 55.7 kDa |
| Formulation | Lyophilized from a 0.22 µm filtered solution in PBS, 200mM L-arginine(pH 7.4). |
| Reconstitution | It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH2O more than 100 µg/ml. |
| Storage & Stability | Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles. |
| Gene ID | 54567 |
|---|---|
| Other Names | Delta-like protein 4, Drosophila Delta homolog 4, Delta4, DLL4 |
| Target Background | Delta-like protein 4 (DLL4) is a type I transmembrane protein with a DSL domain and eight tandem EGF repeats. DLL4 functions as a Notch ligand and activates NOTCH1 and NOTCH4 in the Notch signaling pathway. It is involved in vascular development and homeostasis. DLL4 is involved in vascular development and homeostasis. It is highly expressed in some cancers, such as bladder, breast cancers. |
| Name | DLL4 |
|---|---|
| Function | Involved in the Notch signaling pathway as Notch ligand (PubMed:11134954). Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting (PubMed:20616313). Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types (By similarity). During spinal cord neurogenesis, inhibits V2a interneuron fate (PubMed:17728344). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
| Tissue Location | Expressed in vascular endothelium. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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