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>   首页   >   产品   >   CLEC12A/MICL/CLL-1   

CLEC12A/MICL/CLL-1

     
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Product Information
Primary Accession Q5QGZ9-2
Species Human
Sequence His65-Ala265
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per µg by the LAL method.
Biological Activity Immobilized CLEC12A/MICL/CLL-1, His, Human (Cat.No.: Z03957) at 1 µg/ml (100 µl/Well) on the plate can bind Anti-CLEC12A Antibody, hFc Tag
Expression System HEK293
Theoretical Molecular Weight 24.6 kDa
Formulation Lyophilized from a 0.22 µm filtered solution in PBS, (pH 7.4).
Reconstitution It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH2O more than 100 µg/ml.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.
Additional Information
Target Background CLEC12A, also known as CLL-1 is inhibitory C-type lectin-like receptor with ITIM motif. It can associate with signaling phosphatases SHP-1 and SHP-2. CLEC12A is a potential target due to its high expression in acute myeloid leukemia (AML) cells. And there are various therapeutic approaches using CLEC12A as a target for AML, such as CD3/ CLEC12A antibody. It can recruit unstimulated primary T cells against cancer cells with CLL-1 on the surface.
Protein Information
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

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