AIBP Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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Application ![]()
| WB, IF |
---|---|
Primary Accession | Q8NCW5 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | polyclonal |
Calculated MW | 31675 Da |
Gene ID | 128240 |
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Other Names | NAD(P)H-hydrate epimerase {ECO:0000255|HAMAP-Rule:MF_03159}, Apolipoprotein A-I-binding protein {ECO:0000255|HAMAP-Rule:MF_03159}, AI-BP {ECO:0000255|HAMAP-Rule:MF_03159}, NAD(P)HX epimerase {ECO:0000255|HAMAP-Rule:MF_03159}, YjeF N-terminal domain-containing protein 1, YjeF_N1, APOA1BP {ECO:0000255|HAMAP-Rule:MF_03159} |
Dilution | WB~~ 1:1000 IF~~1:100 |
Format | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.09% (W/V) sodium azide and 50% glycerol. |
Storage Conditions | -20℃ |
Name | NAXE (HGNC:18453) |
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Function | Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) (PubMed:27616477). This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX (By similarity). Accelerates cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis (PubMed:23719382). |
Cellular Location | Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03159}. Secreted {ECO:0000255|HAMAP-Rule:MF_03159, ECO:0000269|PubMed:11991719}. Note=In sperm, secretion gradually increases during capacitation. {ECO:0000255|HAMAP-Rule:MF_03159} |
Tissue Location | Ubiquitously expressed, with highest levels in kidney, heart and liver. Present in cerebrospinal fluid and urine but not in serum from healthy patients. Present in serum of sepsis patients (at protein level). |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX (By similarity).
REFERENCES
Ritter M.,et al.Genomics 79:693-702(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).

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