癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-AKAP2 Picoband Antibody
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Application 
| WB |
|---|---|
| Primary Accession | Q9Y2D5 |
| Host | Rabbit |
| Reactivity | Human, Rat |
| Clonality | Polyclonal |
| Format | Lyophilized |
| Description | Rabbit IgG polyclonal antibody for A-kinase anchor protein 2(AKAP2) detection. Tested with WB in Human;Rat. |
| Reconstitution | Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
| Gene ID | 445815 |
|---|---|
| Other Names | A-kinase anchor protein 2, AKAP-2, AKAP-KL, Protein kinase A-anchoring protein 2, PRKA2, AKAP2, KIAA0920, PRKA2 |
| Calculated MW | 122071 Da |
| Application Details | Western blot, 0.1-0.5 µg/ml, Human, Rat |
| Source | Eukaryota |
| Protein Name | A-kinase anchor protein 2 |
| Contents | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3. |
| Immunogen | A synthetic peptide corresponding to a sequence at the C-terminus of human AKAP2 (813-852aa ETHKSKRRERMDDSSVLEATRVNRRKSALALRWEAGIYAN), identical to the related mouse and rat sequences. |
| Purification | Immunogen affinity purified. |
| Cross Reactivity | No cross reactivity with other proteins. |
| Storage | At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PALM2AKAP2 (HGNC:33529) |
|---|---|
| Function | Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP. Binds to and modulates the structure of the actin cytoskeleton. |
| Cellular Location | Apical cell membrane {ECO:0000250|UniProtKB:O54931}; Lipid-anchor, GPI-like-anchor {ECO:0000250|UniProtKB:O54931}; Cytoplasmic side {ECO:0000250|UniProtKB:O54931}. Note=Accumulates near the inner, apical surface of highly polarized epithelium in tubules of nephrons {ECO:0000250|UniProtKB:O54931} |
| Tissue Location | [Isoform 6]: Expressed in infantile heart and muscle, and fibroblasts. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
A-kinase anchor protein 2 is an enzyme that in humans is encoded by the AKAP2 gene. It is mapped to 9q31.3. The protein encoded by this gene binds to the regulatory subunit of protein kinase A and is found associated with the actin cytoskeleton. The encoded protein mediates signals carried by cAMP and may be involved in creating polarity in certain signaling processes. Three transcript variants encoding different isoforms have been found for this gene.
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