癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
AKAP2/PALM2 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q9Y2D5 |
| Reactivity | Pig, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 122071 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human AKAP2 |
| Epitope Specificity | 151-250/859 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | AKAP2 binds to regulatory subunit (RII) of protein kinase A and can be differentially expressed as a natural AKAP2-PALM2 chimeric protein. It may be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP. There are 2 named isoforms produced by alternative splicing. |
| Gene ID | 445815 |
|---|---|
| Other Names | A-kinase anchor protein 2, AKAP-2, AKAP-KL, Protein kinase A-anchoring protein 2, PRKA2, AKAP2, KIAA0920, PRKA2 |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:50-200,ELISA=1:5000-10000 |
| Format | 0.01M TBS(pH7.4) with 1% BSA, 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| Name | PALM2AKAP2 (HGNC:33529) |
|---|---|
| Function | Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP. Binds to and modulates the structure of the actin cytoskeleton. |
| Cellular Location | Apical cell membrane {ECO:0000250|UniProtKB:O54931}; Lipid-anchor, GPI-like-anchor {ECO:0000250|UniProtKB:O54931}; Cytoplasmic side {ECO:0000250|UniProtKB:O54931}. Note=Accumulates near the inner, apical surface of highly polarized epithelium in tubules of nephrons {ECO:0000250|UniProtKB:O54931} |
| Tissue Location | [Isoform 6]: Expressed in infantile heart and muscle, and fibroblasts. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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