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Anti-Cyclin A Antibody (Monoclonal, CY-A1)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, ICC |
|---|---|
| Primary Accession | P51943 |
| Host | Mouse |
| Isotype | Mouse IgG2a |
| Reactivity | Human, Mouse |
| Clonality | Monoclonal |
| Format | Lyophilized |
| Description | Mouse IgG monoclonal antibody for Cyclin A, cyclin A2 (CCNA2) detection. Tested with WB, ICC in Human;mouse;bovine. No cross reactivity with other proteins. |
| Reconstitution | Add 1ml of PBS buffer will yield a concentration of 100ug/ml. |
| Gene ID | 12428 |
|---|---|
| Other Names | Cyclin-A2, Cyclin-A, Ccna2, Ccna, Cyca |
| Calculated MW | 47269 Da |
| Application Details | Immunocytochemistry , 1 µg/ml, Human, bovine , mouse, - Western blot, 0.5-1 µg/ml, Human, bovine , mouse |
| Subcellular Localization | Nucleus. Cytoplasm. Cytoplasmic when associated with SCAPER. . |
| Tissue Specificity | Ubiquitous. In the testis, expressed in germ cells and in the ovary, in both germline and somatic cells. |
| Source | Eukaryota |
| Protein Name | Cyclin-A2 |
| Contents | Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative. |
| Clone Names | CY-A1 |
| Immunogen | Recombinant bovine cyclin A. |
| Purification | Ascites |
| Cross Reactivity | No cross reactivity with other proteins |
| Storage | At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing. |
| Sequence Similarities | Belongs to the cyclin family. Cyclin AB subfamily. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Ccna2 {ECO:0000312|MGI:MGI:108069} |
|---|---|
| Function | Essential for the control of the cell cycle at G1/S and G2/M transition (By similarity). Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin- dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle (By similarity). |
| Cellular Location | Nucleus. Cytoplasm. Note=Exclusively nuclear during interphase. Detected in the nucleus and the cytoplasm at prophase Cytoplasmic when associated with SCAPER {ECO:0000250|UniProtKB:P20248} |
| Tissue Location | Ubiquitous (PubMed:8565853). In the testis, expressed in germ cells and in the ovary, in both germline and somatic cells (PubMed:10068472, PubMed:8575639). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The mammalian A-type cyclin family consists of 2 members, cyclin A1(CCNA1) and cyclin A2(CCNA2). Human cyclin A gene is assigned to 4q26-q27. Cyclin A protein is synthesized and localized into the nucleus at the onset of S phase in nontransformed mammalian fibroblasts.
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