癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Cyclin A2 Rabbit mAb
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- 背景知识
Application 
| WB, IHC-P, IHC-F |
|---|---|
| Primary Accession | P51943 |
| Reactivity | Rat, Human, Mouse |
| Host | Rabbit |
| Clonality | Monoclonal Antibody |
| Isotype | IgG |
| Conjugate | Unconjugated |
| Purification | Affinity Purified |
| Calculated MW | 47269 Da |
| Gene ID | 12428 |
|---|---|
| Other Names | Ccna2 |
| Dilution | WB~~1:500-1:1000 IHC-P~~1:50~200 IHC-F~~N/A |
| Format | Liquid in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Ccna2 {ECO:0000312|MGI:MGI:108069} |
|---|---|
| Function | Essential for the control of the cell cycle at G1/S and G2/M transition (By similarity). Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin- dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle (By similarity). |
| Cellular Location | Nucleus. Cytoplasm. Note=Exclusively nuclear during interphase. Detected in the nucleus and the cytoplasm at prophase Cytoplasmic when associated with SCAPER {ECO:0000250|UniProtKB:P20248} |
| Tissue Location | Ubiquitous (PubMed:8565853). In the testis, expressed in germ cells and in the ovary, in both germline and somatic cells (PubMed:10068472, PubMed:8575639). |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.
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