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Anti-CETP Antibody
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Application 
| WB |
|---|---|
| Primary Accession | P11597 |
| Host | Rabbit |
| Reactivity | Human |
| Clonality | Polyclonal |
| Format | Lyophilized |
| Description | Rabbit IgG polyclonal antibody for Cholesteryl ester transfer protein(CETP) detection. Tested with WB in Human. |
| Reconstitution | Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
| Gene ID | 1071 |
|---|---|
| Other Names | Cholesteryl ester transfer protein, Lipid transfer protein I {ECO:0000312|MIM:118470}, CETP (HGNC:1869) |
| Calculated MW | 54756 Da |
| Application Details | Western blot, 0.1-0.5 µg/ml, Human |
| Subcellular Localization | Secreted, extracellular space . Secreted in plasma. . |
| Tissue Specificity | Expressed by the liver and secreted in plasma. |
| Source | Eukaryota |
| Protein Name | Cholesteryl ester transfer protein |
| Contents | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Immunogen | A synthetic peptide corresponding to a sequence at the C-terminus of human CETP(368-382aa PRPDQQHSVAYTFEE). |
| Purification | Immunogen affinity purified. |
| Cross Reactivity | No cross reactivity with other proteins |
| Storage | At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing. |
| Sequence Similarities | Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CETP (HGNC:1869) |
|---|---|
| Function | Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL (PubMed:24293641, PubMed:3281933, PubMed:3600759). Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination (PubMed:17237796). |
| Cellular Location | Secreted. Note=Secreted in plasma |
| Tissue Location | Expressed by the liver and secreted in plasma. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
CETP(Cholesteryl Ester Transfer Protein Plasma), is a plasma protein that facilitates the transport of cholesteryl esters and triglycerides between the lipoproteins. CETP is also known as lipid transfer protein I(Day et al., 1994). Sparkes et al.(1987) used a CETP probe against DNA from a human/mouse somatic cell hybrid panel to assign the CETP gene to chromosome 16. Because the role of CETP in atherosclerosis remained unclear, Okamoto et al.(2000) attempted to develop a potent, specific CETP inhibitor. One inhibitor, JTT-705, forms a disulfide bond with CETP and increases high density lipoprotein(HDL) cholesterol, decreases non-HDL cholesterol, and inhibits the progression of atherosclerosis in rabbits.
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