癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-Superoxide Dismutase 3 Rabbit Monoclonal Antibody
- 产品详情
- 实验流程
Application 
| WB, IHC |
|---|---|
| Primary Accession | P08294 |
| Host | Rabbit |
| Isotype | IgG |
| Reactivity | Human |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-Superoxide Dismutase 3 Rabbit Monoclonal Antibody . Tested in WB, IHC applications. This antibody reacts with Human. |
| Gene ID | 6649 |
|---|---|
| Other Names | Extracellular superoxide dismutase [Cu-Zn], EC-SOD, 1.15.1.1, SOD3 |
| Calculated MW | 25851 Da |
| Application Details | WB 1:500-1:2000 IHC 1:50-1:200 |
| Source | Eukaryota |
| Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| Clone Names | Clone: 17S81 |
| Immunogen | A synthesized peptide derived from human Superoxide Dismutase 3 |
| Purification | Affinity-chromatography |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SOD3 (HGNC:11181) |
|---|---|
| Function | Secreted antioxidant enzyme that acts as the primary scavenger of superoxide radicals in the extracellular space, converting them to hydrogen peroxide and thereby protecting tissues from oxidative damage (PubMed:12933702, PubMed:15761197). Also preserves nitric oxide bioavailability by preventing the formation of harmful peroxynitrite (PubMed:12933702). Stored in intracellular pre-formed vesicles of macrophages and neutrophils and released upon stimulation by inflammatory mediators (PubMed:31326693). |
| Cellular Location | Secreted, extracellular space. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:O09164}. Vesicle Note=99% of SOD3/EC-SOD is anchored to heparan sulfate proteoglycans in the tissue interstitium, and 1% is located in the vasculature in equilibrium between the plasma and the endothelium (PubMed:8546689). In macrophages and neutrophiles, extracellular SOD2 in endocytosed and stored in intracellular vesicles (PubMed:31326693) |
| Tissue Location | Expressed in blood vessels, heart, lung, kidney and placenta. Major SOD isoenzyme in extracellular fluids such as plasma, lymph and synovial fluid (PubMed:7959763). Stored in macrophages intracellular compartments (PubMed:31326693) |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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