Anti-RAB5C / RABL Rabbit Monoclonal Antibody

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB, IHC, IF, ICC
Primary Accession	P51148
Host	Rabbit
Isotype	IgG
Reactivity	Rat, Human, Mouse
Clonality	Monoclonal
Format	Liquid
Description	Anti-RAB5C / RABL Rabbit Monoclonal Antibody . Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human, Mouse, Rat.

Additional Information
Gene ID	5878
Other Names	Ras-related protein Rab-5C, 3.6.5.2, L1880, RAB5L, RAB5C, RABL
Calculated MW	23483 Da
Application Details	WB 1:500-1:2000 IHC 1:50-1:200 ICC/IF 1:50-1:200
Source	Eukaryota
Contents	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
Clone Names	Clone: 28R55
Immunogen	A synthesized peptide derived from human RAB5C / RABL
Purification	Affinity-chromatography
Storage	Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

For Research Use Only. Not For Use In Diagnostic Procedures.

Protein Information
Name	RAB5C (HGNC:9785)
Synonyms	RABL
Function	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:16086013, PubMed:17562788). Involved in early endocytic trafficking (PubMed:16086013, PubMed:17562788). Required for EEA1 recruitment to early endosomes (PubMed:16086013, PubMed:17562788). Required for EGF and transferrin endocytosis and trafficking through early endosomes (PubMed:16086013, PubMed:17562788).
Cellular Location	Cell membrane {ECO:0000250\|UniProtKB:P20339}; Lipid-anchor {ECO:0000250\|UniProtKB:P20339}; Cytoplasmic side {ECO:0000250\|UniProtKB:P20339}. Early endosome membrane {ECO:0000250\|UniProtKB:P20339}; Lipid-anchor {ECO:0000250\|UniProtKB:P20339}. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV