Anti-Phospho-PLCB3 (S537) Rabbit Monoclonal Antibody

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB
Primary Accession	Q01970
Host	Rabbit
Isotype	Rabbit IgG
Reactivity	Human
Clonality	Monoclonal
Format	Liquid
Description	Anti-Phospho-PLCB3 (S537) Rabbit Monoclonal Antibody . Tested in WB applications. This antibody reacts with Human.

Additional Information
Gene ID	5331
Other Names	1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase beta-3, 3.1.4.11, Phosphoinositide phospholipase C-beta-3, Phospholipase C-beta-3, PLC-beta-3, PLCB3 {ECO:0000312\|EMBL:AAA77683.1}
Calculated MW	138799 Da
Application Details	WB 1:500-1:2000
Source	Eukaryota
Contents	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
Clone Names	Clone: 32P57
Immunogen	A synthesized peptide derived from human Phospho-PLCB3 (S537)
Purification	Affinity-chromatography
Storage	Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

For Research Use Only. Not For Use In Diagnostic Procedures.

Protein Information
Name	PLCB3 {ECO:0000303\|PubMed:20966218, ECO:0000312\|EMBL:AAA77683.1}
Function	Catalyzes the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (PubMed:20966218, PubMed:29122926, PubMed:37172014, PubMed:37991948, PubMed:9188725). Key transducer of G protein-coupled receptor signaling: activated by G(q)/G(11) G alpha proteins downstream of G protein-coupled receptors activation (PubMed:20966218, PubMed:37991948). In neutrophils, participates in a phospholipase C- activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting RASGRP4 activation by DAG, to promote neutrophil functional responses (By similarity). In conjunction with OSBPL2, it may contribute to the control of keratinocyte proliferation and differentiation, probably through the regulation of the ERK pathway and the cell cycle (PubMed:38701954).
Cellular Location	Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus {ECO:0000250\|UniProtKB:P51432} Note=An heterotetramer composed of GNG2 and GNB1 increases the concentration of PLCB3 on the membrane surface, where its substrate PIP2 resides, by orienting its catalytic site