Anti-PD-L1 (Atezolizumab), humanized Antibody
Human Monoclonal Antibody
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Application ![]()
| E |
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Primary Accession | Q9NZQ7 |
Reactivity | Human |
Host | Human |
Clonality | Monoclonal |
Isotype | Human IgG1 |
Clone Names | N/A |
Calculated MW | 33275 Da |
Gene ID | 29126 |
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Other Names | Tecentriq, PD-L1 |
Target/Specificity | PD-L1 |
Antibody Form | Liquid |
Appearance | Colorless liquid |
Formulation | In phosphate buffered saline, pH 7.4 |
Handling | The antibody solution should be gently mixed before use. |
Reconstitution & Storage | -20 °C |
Background Descriptions | |
Precautions | Anti-PD-L1 (Atezolizumab), humanized Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CD274 (HGNC:17635) |
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Function | Plays a critical role in induction and maintenance of immune tolerance to self (PubMed:11015443, PubMed:28813410, PubMed:28813417, PubMed:31399419). As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11015443, PubMed:28813410, PubMed:28813417, PubMed:36727298). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:10581077). Can also act as a transcription coactivator: in response to hypoxia, translocates into the nucleus via its interaction with phosphorylated STAT3 and promotes transcription of GSDMC, leading to pyroptosis (PubMed:32929201). |
Cellular Location | Cell membrane; Single-pass type I membrane protein. Early endosome membrane; Single-pass type I membrane protein. Recycling endosome membrane; Single-pass type I membrane protein. Nucleus. Note=Associates with CMTM6 at recycling endosomes, where it is protected from being targeted for lysosomal degradation (PubMed:28813417). Translocates to the nucleus in response to hypoxia via its interaction with phosphorylated STAT3 (PubMed:32929201). [Isoform 2]: Endomembrane system; Single-pass type I membrane protein |
Tissue Location | Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Atezolizumab (Tecentriq) is a fully humanized, engineered monoclonal antibody of IgG1 isotype against the protein programmed cell death-ligand 1 (PD-L1). Atezolizumab blocks the interaction of PD-L1 with PD-1 and induces anti-tumor immune reactivation.

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Discontinued
Cat# ABV12036
Size:
100 µg
Price:
¥ 4,980.00
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