CD38

Rabbit Monoclonal antibody(Mab)

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	IHC-P
Primary Accession	P28907
Reactivity	Human
Host	Rabbit
Clonality	Monoclonal
Clone Names	645J4B5
Calculated MW	34328 Da

Additional Information
Gene ID	952
Gene Name	CD38
Other Names	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, 3.2.2.-, 3.2.2.6, 2'-phospho-ADP-ribosyl cyclase, 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase, 2.4.99.20, 2'-phospho-cyclic-ADP-ribose transferase, ADP-ribosyl cyclase 1, ADPRC 1, Cyclic ADP-ribose hydrolase 1, cADPR hydrolase 1, T10, CD38, CD38
Dilution	IHC-P~~Ready-to-use
Storage	Maintain refrigerated at 2-8°C.
Precautions	CD38 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Protein Information
Name	CD38
Function	Synthesizes cyclic ADP-ribose (cADPR), a second messenger for glucose-induced insulin secretion (PubMed:7961800, PubMed:8253715). Synthesizes the Ca(2+) mobilizer nicotinate-adenine dinucleotide phosphate, NAADP(+), from 2'-phospho-cADPR and nicotinic acid, as well as from NADP(+) and nicotinic acid. At both pH 5.0 and pH 7.4 preferentially transforms 2'-phospho-cADPR into NAADP(+), while preferentially cleaving NADP(+) to cADPR and ADPRP rather than into NADDP(+) (PubMed:16690024). Has cADPR hydrolase activity (PubMed:7961800, PubMed:8253715).
Cellular Location	Cell surface. Membrane; Single-pass type II membrane protein
Tissue Location	Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.