癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SOD1, Biotinylated
Peptide-affinity purified goat antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, Pep-ELISA |
|---|---|
| Primary Accession | P00441 |
| Other Accession | NP_000445, 6647, 20655 (mouse), 24786 (rat) |
| Reactivity | Human, Mouse, Rat |
| Predicted | Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 15936 Da |
| Gene ID | 6647 |
|---|---|
| Other Names | Superoxide dismutase [Cu-Zn], 1.15.1.1, Superoxide dismutase 1, hSod1, SOD1 |
| Dilution | WB~~1:1000 Pep-ELISA~~N/A |
| Format | 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SOD1, Biotinylated is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SOD1 (HGNC:11179) |
|---|---|
| Function | Destroys radicals which are normally produced within the cells and which are toxic to biological systems. |
| Cellular Location | Cytoplasm. Nucleus. Note=Predominantly cytoplasmic; the pathogenic variants ALS1 Arg-86 and Ala-94 gradually aggregates and accumulates in mitochondria. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene.
REFERENCES
Chromosome 9p21 in amyotrophic lateral sclerosis in Finland: a genome-wide association study. Laaksovirta H, et al. Lancet Neurol, 2010 Oct. PMID 20801718.
Knock-down of superoxide dismutase 1 sensitizes cisplatin-resistant human ovarian cancer cells. Kim JW, et al. Anticancer Res, 2010 Jul. PMID 20682985.
Genetics and clinical characteristics of keratoconus. Stabuc-Silih M, et al. Acta Dermatovenerol Alp Panonica Adriat, 2010. PMID 20664914.
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
Mutant superoxide dismutase 1-induced IL-1beta accelerates ALS pathogenesis. Meissner F, et al. Proc Natl Acad Sci U S A, 2010 Jul 20. PMID 20616033.
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