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> 首页 > 产品 > 一抗 > 精选抗体 > Inflammatory response > Goat Anti-AIMP1 / SCYE1 Antibody (aa137-149) (internal region), Biotinylated
Goat Anti-AIMP1 / SCYE1 Antibody (aa137-149) (internal region), Biotinylated
- 产品详情
- 实验流程
Application 
| WB, E |
|---|---|
| Primary Accession | Q12904 |
| Other Accession | NP_004748.2, NP_001135888.1, 9255 |
| Reactivity | Human |
| Predicted | Human, Pig, Dog |
| Host | Goat |
| Isotype | IgG |
| Calculated MW | 34353 Da |
| Gene ID | 9255 |
|---|---|
| Other Names | Aminoacyl tRNA synthase complex-interacting multifunctional protein 1, Multisynthase complex auxiliary component p43, Endothelial monocyte-activating polypeptide 2, EMAP-2, Endothelial monocyte-activating polypeptide II, EMAP-II, Small inducible cytokine subfamily E member 1, AIMP1, EMAP2, SCYE1 |
| Dilution | WB~~1:1000 E~~N/A |
| Immunogen | This antibody is expected to recognize both reported isoforms (NP_004748.2; NP_001135888.1). Reported variants represent identical protein: NP_004748.2, NP_001135887.1 |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat Anti-AIMP1 / SCYE1 Antibody (aa137-149) (internal region), Biotinylated is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | AIMP1 |
|---|---|
| Synonyms | EMAP2, SCYE1 |
| Function | Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase (PubMed:10358004). Binds tRNA. Possesses inflammatory cytokine activity (PubMed:11306575). Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7- mediated degradation (By similarity). Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels (By similarity). Promotes dermal fibroblast proliferation and wound repair (PubMed:16472771). Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum (By similarity). Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations (PubMed:12237313). Induces maturation of dendritic cells and monocyte cell adhesion (PubMed:11818442). Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7 (PubMed:19362550). |
| Cellular Location | Nucleus. Cytoplasm, cytosol. Secreted. Endoplasmic reticulum {ECO:0000250|UniProtKB:P31230}. Golgi apparatus {ECO:0000250|UniProtKB:P31230}. Note=Enriched in secretory vesicles of pancreatic alpha cells and secreted from the pancreas in response to low glucose levels (By similarity). Secreted in response to hypoxia (PubMed:10850427). Also secreted in response to both apoptotic and necrotic cell death. {ECO:0000250|UniProtKB:P31230, ECO:0000269|PubMed:10850427} |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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