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Goat Anti-GABRG2 Antibody (aa384-396) (internal region)
- 产品详情
- 实验流程
Application 
| WB, E |
|---|---|
| Primary Accession | P18507 |
| Other Accession | NP_944494.1, NP_000807.2, NP_944493.2, 29709, 14406, 2566 |
| Reactivity | Human, Mouse, Rat, Pig |
| Predicted | Human, Mouse, Rat, Pig, Dog |
| Host | Goat |
| Isotype | IgG |
| Calculated MW | 55186 Da |
| Gene ID | 2566 |
|---|---|
| Other Names | Gamma-aminobutyric acid receptor subunit gamma-2, GABA(A) receptor subunit gamma-2, GABRG2 |
| Dilution | WB~~1:1000 E~~N/A |
| Immunogen | This antibody is expected to recognize all three reported isoforms (NP_944494.1; NP_000807.2; NP_944493.2). |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat Anti-GABRG2 Antibody (aa384-396) (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GABRG2 (HGNC:4087) |
|---|---|
| Function | Gamma subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:14993607, PubMed:16412217, PubMed:23909897, PubMed:2538761, PubMed:25489750, PubMed:27864268, PubMed:29950725, PubMed:30602789). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (PubMed:29950725, PubMed:30602789). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:14993607, PubMed:16412217, PubMed:2538761, PubMed:27864268, PubMed:29950725, PubMed:30602789). Gamma-2/GABRG2-containing GABAARs are found at both synaptic and extrasynaptic sites (By similarity). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (By similarity). GABAARs containing alpha-1 and beta-2 or -3 subunits exhibit synaptogenic activity; the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation (PubMed:23909897, PubMed:25489750). Extrasynaptic gamma-2- containing receptors contribute to the tonic GABAergic inhibition (By similarity). GABAARs function also as histamine receptor where histamine binds at the interface of two neighboring beta subunits and potentiates GABA response in a gamma-2 subunit-controlled manner (By similarity). |
| Cellular Location | Postsynaptic cell membrane; Multi-pass membrane protein {ECO:0000269|PubMed:30602789, ECO:0007744|PDB:6I53}. Cell membrane; Multi-pass membrane protein {ECO:0000269|PubMed:30602789, ECO:0007744|PDB:6I53} Cell projection, dendrite {ECO:0000250|UniProtKB:P22723}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P18508} |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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