癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-Oxoglutarate receptor 1 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q96P68 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB4575 |
| Calculated MW | 38251 Da |
| Gene Name | OXGR1 |
| Aliases | OXGR1; Oxoglutarate Receptor 1; P2RY15; P2Y15; Alpha-Ketoglutarate Receptor 1; 2-Oxoglutarate Receptor 1; GPR80; GPR99; AKGR; Oxoglutarate (Alpha-Ketoglutarate) Receptor 1; G Protein-Coupled Receptor 80; G-Protein Coupled Receptor 99; P2Y-Like Nucleotide Receptor; P2Y Purinoceptor 15; P2Y-Like GPCR; Seven Transmembrane Helix Receptor; G-Protein Coupled Receptor 80; CAON2 |
| Immunogen | A synthesized peptide derived from human OXGR1 / GPR99 |
| Gene ID | 27199 |
|---|---|
| Other Names | 2-oxoglutarate receptor 1, Alpha-ketoglutarate receptor 1, G-protein coupled receptor 80, G-protein coupled receptor 99, P2Y purinoceptor 15, P2Y15, P2Y-like GPCR, P2Y-like nucleotide receptor, OXGR1 |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | OXGR1 {ECO:0000303|PubMed:36919698, ECO:0000312|HGNC:HGNC:4531} |
|---|---|
| Function | G protein-coupled receptor for dicarboxylates and amino dicarboxylates, such as alpha-ketoglutarate, itaconate and leukotriene E4 (PubMed:15141213, PubMed:36571463, PubMed:36919698, PubMed:41413034, PubMed:41791372). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as phospholipase C (PubMed:41413034, PubMed:41791372). OXGR1 is coupled to G(q) G proteins and mediates production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (PubMed:36919698, PubMed:41413034, PubMed:41791372). Activation by alpha-ketoglutarate produced by proximal tubule renal cells upon metabolic alkalosis initiates an intrarenal paracrine signaling pathway that drives transepithelial salt reabsorption and bicarbonate secretion by SLC26A4/pendrin-positive intercalated cells (By similarity). Also acts as a regulator of vasodilatation in vascular smooth muscle cells: following activation by alpha-ketoglutarate, couples to GNAQ/G(q), initiating a signaling that activates MYLK/MLCK, thereby promoting MYL9 phosphorylation and vascular smooth muscle cell contraction and limiting vasodilation (PubMed:41791372). Receptor for itaconate, a metabolite produced by myeloid lineages (PubMed:36919698). In the respiratory epithelium, couples the binding of itaconate to the activation of GNA11/G(11) and downstream intracellular Ca(2+) release, leading to mucocilliary clearance of airborne pathogens (PubMed:36919698). Receptor for leukotriene E4 (LTE4) produced by mast cells upon allergic inflammation (PubMed:41413034). Binds with high affinity to LTE4 and elicits mucin release from pulmonary epithelium in response to airborne fungi allergens (By similarity). Regulates mucin-producing goblet cell homeostasis (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Note=Upon itaconate binding, internalizes via endocytosis in a beta-arrestin dependent manner |
| Tissue Location | Detected in kidney and, to a lower extent, in placenta (PubMed:12098360). Not detected in brain tissues including the frontal cortex, caudate putamen, thalamus, hypothalamus, hippocampus or pons (PubMed:12098360). |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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