癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
OXGR1 / GPR99 Antibody
Rabbit mAb
- 产品详情
- 实验流程
Application 
| WB, IF, FC, ICC |
|---|---|
| Primary Accession | Q96P68 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Other Names | GPR80; GPR99; Oxgr1; P2RY15; P2Y15; |
| Isotype | Rabbit IgG |
| Host | Rabbit |
| Calculated MW | 38251 Da |
| Dilution | WB 1:500~1:2000 ICC/IF 1:50~1:200 FC 1:50 |
|---|---|
| Purification | Affinity-chromatography |
| Immunogen | A synthesized peptide derived from human OXGR1 / GPR99 |
| Description | Receptor for alpha-ketoglutarate. Seems to act exclusively through a G(q)-mediated pathway. |
| Storage Condition and Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | OXGR1 {ECO:0000303|PubMed:36919698, ECO:0000312|HGNC:HGNC:4531} |
|---|---|
| Function | G protein-coupled receptor for dicarboxylates and amino dicarboxylates, such as alpha-ketoglutarate, itaconate and leukotriene E4 (PubMed:15141213, PubMed:36571463, PubMed:36919698, PubMed:41413034, PubMed:41791372). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as phospholipase C (PubMed:41413034, PubMed:41791372). OXGR1 is coupled to G(q) G proteins and mediates production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (PubMed:36919698, PubMed:41413034, PubMed:41791372). Activation by alpha-ketoglutarate produced by proximal tubule renal cells upon metabolic alkalosis initiates an intrarenal paracrine signaling pathway that drives transepithelial salt reabsorption and bicarbonate secretion by SLC26A4/pendrin-positive intercalated cells (By similarity). Also acts as a regulator of vasodilatation in vascular smooth muscle cells: following activation by alpha-ketoglutarate, couples to GNAQ/G(q), initiating a signaling that activates MYLK/MLCK, thereby promoting MYL9 phosphorylation and vascular smooth muscle cell contraction and limiting vasodilation (PubMed:41791372). Receptor for itaconate, a metabolite produced by myeloid lineages (PubMed:36919698). In the respiratory epithelium, couples the binding of itaconate to the activation of GNA11/G(11) and downstream intracellular Ca(2+) release, leading to mucocilliary clearance of airborne pathogens (PubMed:36919698). Receptor for leukotriene E4 (LTE4) produced by mast cells upon allergic inflammation (PubMed:41413034). Binds with high affinity to LTE4 and elicits mucin release from pulmonary epithelium in response to airborne fungi allergens (By similarity). Regulates mucin-producing goblet cell homeostasis (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Note=Upon itaconate binding, internalizes via endocytosis in a beta-arrestin dependent manner |
| Tissue Location | Detected in kidney and, to a lower extent, in placenta (PubMed:12098360). Not detected in brain tissues including the frontal cortex, caudate putamen, thalamus, hypothalamus, hippocampus or pons (PubMed:12098360). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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