癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-Adenylate kinase 4 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC |
|---|---|
| Primary Accession | P27144 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB4755 |
| Calculated MW | 25268 Da |
| Gene Name | AK4 |
| Aliases | AK4; Adenylate Kinase 4; AK3L1; AK3; Adenylate Kinase 4, Mitochondrial; Adenylate Kinase 3-Like 1; AK 4; GTP:AMP Phosphotransferase AK4, Mitochondrial; Adenylate Kinase Isoenzyme 4, Mitochondrial; Epididymis Secretory Sperm Binding Protein; Nucleoside-Triphosphate-Adenylate Kinase; Mitochondrial Adenylate Kinase-3; GTP:AMP Phosphotransferase AK4; ATP-AMP Transphosphorylase; Adenylate Kinase 3-Like; Adenylate Kinase 3; EC 2.7.4.10; EC 2.7.4.6; EC 2.7.4.3; EC 2.7.4; AK3L2 |
| Immunogen | A synthesized peptide derived from human Adenylate kinase 4 |
| Gene ID | 205 |
|---|---|
| Other Names | Adenylate kinase 4, mitochondrial, 2.7.4.4, 2.7.4.6, Adenylate kinase 3-like {ECO:0000255|HAMAP-Rule:MF_03170}, GTP:AMP phosphotransferase AK4 {ECO:0000255|HAMAP-Rule:MF_03170}, AK4 (HGNC:363) |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | AK4 (HGNC:363) |
|---|---|
| Function | Broad-specificity mitochondrial nucleoside phosphate kinase involved in cellular nucleotide homeostasis by catalyzing nucleoside- phosphate interconversions (PubMed:19073142, PubMed:19766732, PubMed:23416111, PubMed:24767988). Similar to other adenylate kinases, preferentially catalyzes the phosphorylation of the nucleoside monophosphate AMP with ATP as phosphate donor to produce ADP (PubMed:19766732). Phosphorylates only AMP when using GTP as phosphate donor (PubMed:19766732). In vitro, can also catalyze the phosphorylation of CMP, dAMP and dCMP and use GTP as an alternate phosphate donor (PubMed:19766732, PubMed:23416111). Moreover, exhibits a diphosphate kinase activity, producing ATP, CTP, GTP, UTP, TTP, dATP, dCTP and dGTP from the corresponding diphosphate substrates with either ATP or GTP as phosphate donors (PubMed:23416111). Plays a role in controlling cellular ATP levels by regulating phosphorylation and activation of the energy sensor protein kinase AMPK (PubMed:24767988, PubMed:26980435). Plays a protective role in the cellular response to oxidative stress (PubMed:19130895, PubMed:23474458, PubMed:26980435). |
| Cellular Location | Mitochondrion matrix {ECO:0000255|HAMAP- Rule:MF_03170, ECO:0000269|PubMed:11485571, ECO:0000269|PubMed:19766732, ECO:0000269|PubMed:26980435} |
| Tissue Location | Highly expressed in kidney, moderately expressed in heart and liver and weakly expressed in brain |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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