癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-VPS41 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | P49754 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 25GB4595 |
| Calculated MW | 98566 Da |
| Gene Name | VPS41 |
| Aliases | VPS41; VPS41 Subunit Of HOPS Complex; HVSP41; Vacuolar Protein Sorting-Associated Protein 41 Homolog; VPS41, HOPS Complex Subunit; S53; Vacuolar Protein Sorting 41 Homolog (S. Cerevisiae); Vacuolar Protein Sorting 41 (Yeast Homolog); Vacuolar Protein Sorting 41 (Yeast); Vacuolar Protein Sorting 41 Homolog; Vacuolar Assembly Protein 41; HVps41p; HVPS41; SCAR29 |
| Immunogen | A synthesized peptide derived from human VPS41 |
| Gene ID | 27072 |
|---|---|
| Other Names | Vacuolar protein sorting-associated protein 41 homolog, S53, VPS41 |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | VPS41 |
|---|---|
| Function | Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Acts as a component of the HOPS endosomal tethering complex. This complex is proposed to be involved in the Rab5- to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes (PubMed:23351085, PubMed:33851776). Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes implicated in degradation of endocytosed cargo (PubMed:23167963, PubMed:25445562, PubMed:25908847, PubMed:9159129). Required for fusion of autophagosomes with lysosomes (PubMed:25783203, PubMed:37821429). Links the HOPS complex to endosomal Rab7 via its association with RILP and to lysosomal membranes via its association with ARL8B, suggesting that these interactions may bring the compartments to close proximity for fusion (PubMed:21802320, PubMed:25445562, PubMed:25908847). Involved in the direct trans-Golgi network to late endosomes transport of lysosomal membrane proteins independently of HOPS (PubMed:23322049). Involved in sorting to the regulated secretory pathway presumably implicating the AP-3 adapter complex (By similarity). May play a role in HOPS-independent function in the regulated secretory pathway (PubMed:24210660). |
| Cellular Location | Endosome membrane; Peripheral membrane protein. Late endosome membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein. Lysosome membrane; Peripheral membrane protein. Golgi apparatus, trans- Golgi network. Cytoplasmic vesicle, clathrin-coated vesicle. Cytoplasm, cytosol |
| Tissue Location | Expressed in cerebral cortex and cerebellum. Highly expressed in Purkinje cells. |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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