癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
> 首页 > 产品 > 一抗 > 癌症 > Ep-CAM / CD326 (Epithelial Marker)
Mouse Monoclonal Antibody [Clone EGP40/837]
Ep-CAM / CD326 (Epithelial Marker) Mouse Monoclonal Antibody [Clone EGP40/837]
Purified Mouse Monoclonal Antibody
![1 - Ep-CAM / CD326 (Epithelial Marker)
Mouse Monoclonal Antibody [Clone EGP40/837] AH10372](/assets/uploads/products/201506/AH10372_FC_1.jpg)
- 产品详情
- 实验流程
Application 
| IF, FC |
|---|---|
| Primary Accession | P16422 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1, kappa |
| Clone Names | EGP40/837 |
| Calculated MW | 34932 Da |
| Gene ID | 4072 |
|---|---|
| Other Names | Adenocarcinoma-associated Antigen; Cell Surface Glycoprotein Trop-1; EGP2; EGP314; EGP40; Epithelial Cell Adhesion Molecule; Epithelial Glycoprotein 314; ESA; KSA; TACD1; TACSTD1; TROP1; Tumor-associated Calcium Signal Transducer 1, ECS-1, Epidermal Surface Antigen 1, ESA1, FLOT2, Flotillin-2, M17S1 (Membrane Component, Chromosome 17, Surface Marker-1), REG-1, Reggie-1, Reggie-2 |
| Target/Specificity | Recombinant full-length human TACSTD1 protein |
| Application Note | Flow Cytometry (0.5-1ug/million cells); Immunofluorescence (0.5-1ug/ml for 30 min at RT) (Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes) Optimal dilution for a specific application should be determined. |
| Format | 0.5ml at 100ug/ml with BSA and azide |
| Storage | Store at 2 to 8°C.Antibody is stable for 24 months. |
| Precautions | Ep-CAM / CD326 (Epithelial Marker) Mouse Monoclonal Antibody [Clone EGP40/837] is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | EPCAM |
|---|---|
| Synonyms | GA733-2, M1S2, M4S1, MIC18, TACSTD1, TRO |
| Function | May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E. |
| Cellular Location | Lateral cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Note=Colocalizes with CLDN7 at the lateral cell membrane and tight junction |
| Tissue Location | Highly and selectively expressed by undifferentiated rather than differentiated embryonic stem cells (ESC) Levels rapidly diminish as soon as ESC's differentiate (at protein levels). Expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinoma. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Bjork, P., Jonsson, U., Svedberg, H., Larsson, K., Lind, P., Dillner, J., Hedlund, G., Dohlsten, M. and Kalland, T. 1993. Isolation, partial characterization, and molecular cloning of a human colon adenocarcinoma cell-surface glyco- protein recognized by the C215 mouse monoclonal antibody. J. Biol. Chem. 268: 24232-24241.
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