癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CDw75 (B-Cell Marker) Antibody - With BSA and Azide
Mouse Monoclonal Antibody [Clone LN-1 ]
- 产品详情
- 实验流程
- 背景知识
Application 
| IHC, IF, FC |
|---|---|
| Primary Accession | P15907 |
| Other Accession | 6480, 207459 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse / IgM, kappa |
| Clone Names | LN-1 |
| Calculated MW | 46605 Da |
| Gene ID | 6480 |
|---|---|
| Other Names | Beta-galactoside alpha-2, 6-sialyltransferase 1, Alpha 2, 6-ST 1, 2.4.99.1, B-cell antigen CD75, CMP-N-acetylneuraminate-beta-galactosamide-alpha-2, 6-sialyltransferase 1, ST6Gal I, ST6GalI, Sialyltransferase 1, ST6GAL1, SIAT1 |
| Application Note | IHC~~1:100~500 IF~~1:50~200 FC~~1:10~50 |
| Storage | Store at 2 to 8°C.Antibody is stable for 24 months. |
| Precautions | CDw75 (B-Cell Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ST6GAL1 |
|---|---|
| Synonyms | SIAT1 |
| Function | Transfers sialic acid from CMP-sialic acid to galactose- containing acceptor substrates. In B lymphocytes, generates neuraminidase-sensitive lymphocyte cell-surface differentiation antigens, such as CDw75, HB-6 and CD76 (PubMed:1730763). |
| Cellular Location | Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted {ECO:0000250|UniProtKB:P13721}. Note=Membrane-bound form in trans cisternae of Golgi (PubMed:20378551). Secreted into the body fluid (By similarity). {ECO:0000250|UniProtKB:P13721, ECO:0000269|PubMed:20378551} |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Recognizes a neuraminidase-sensitive sialoprotein (CDw75), present on cell membrane and cytoplasm of germinal center B-cells and derived lymphomas. This MAb reacts with RBC precursors of bone marrow, ductal and ciliated epithelial cells of kidney, breast, prostate, pancreas, lung, and with glioblastomas, astrocytomas, and Reed Sternberg cells in lymphocyte predominant Hodgkin s disease. It is shown to be a helpful antibody for ascribing a B-cell phenotype in known lymphoid tissues.
REFERENCES
Epstein AL et. al. J of Immunology 133: 1028-1036, 1984. | Marder RJ et. al. Lab Invest 52: 497-504, 1985. |
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