癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Cytokeratin 5/8 Antibody - With BSA and Azide
Mouse Monoclonal Antibody [Clone C-50 ]
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IF, FC, IHC-P |
|---|---|
| Primary Accession | P13647 |
| Other Accession | 3852 (CK5), 3856 (CK8), 433845 (CK5), 533782, 708445 (CK8), P05787 (CK8) |
| Reactivity | Human, Mouse, Rat, Hamster, Pig, Bovine, Sheep, Dog |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse / IgG1, kappa |
| Clone Names | C-50 |
| Calculated MW | 62378 Da |
| Gene ID | 3852 |
|---|---|
| Other Names | Keratin, type II cytoskeletal 5, 58 kDa cytokeratin, Cytokeratin-5, CK-5, Keratin-5, K5, Type-II keratin Kb5, KRT5 |
| Application Note | WB~~1:1000 IF~~1:50~200 FC~~1:10~50 IHC-P~~N/A |
| Storage | Store at 2 to 8°C.Antibody is stable for 24 months. |
| Precautions | Cytokeratin 5/8 Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KRT5 |
|---|---|
| Function | Required for the formation of keratin intermediate filaments in the basal epidermis and maintenance of the skin barrier in response to mechanical stress (By similarity). Regulates the recruitment of Langerhans cells to the epidermis, potentially by modulation of the abundance of macrophage chemotactic cytokines, macrophage inflammatory cytokines and CTNND1 localization in keratinocytes (By similarity). |
| Cellular Location | Cytoplasm. |
| Tissue Location | Expressed in corneal epithelium (at protein level) (PubMed:26758872). Expressed in keratinocytes (at protein level) (PubMed:20128788, PubMed:31302245). |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
It reacts with keratin 5 (58kDa) and keratin 8 (52.5kDa). Simple epithelia express cytokeratin 8 in combination with 18. On the other hand, basal cells of stratified epithelia express cytokeratin 5 paired with 14. This antibody therefore, reacts with a wide range of epithelia and their carcinomas.
REFERENCES
Vojtĕšek et al. Folia Biol. 37(3-4): 197-206 (1991). | B�rtkov� et al. Neoplasma 38(4), 439-46 (1991). | B�rtek et al. J. of Pathology 164, 215-24 (1991). | Kovař�k et al. J. Tumor Marker Oncol. 5, 219 (1990)
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