癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
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FOXE1 antibody - middle region
Rabbit Polyclonal Antibody
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Application 
| WB |
|---|---|
| Primary Accession | O00358 |
| Other Accession | O00358, NP_004464, NM_004473 |
| Reactivity | Human, Mouse, Rat, Pig, Guinea Pig, Bovine |
| Predicted | Human, Mouse, Rat, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 38076 Da |
| Gene ID | 2304 |
|---|---|
| Alias Symbol | FKHL15, FOXE2, HFKH4, HFKL5, TITF2, TTF-2, TTF2 |
| Other Names | Forkhead box protein E1, Forkhead box protein E2, Forkhead-related protein FKHL15, HFKH4, HNF-3/fork head-like protein 5, HFKL5, Thyroid transcription factor 2, TTF-2, FOXE1, FKHL15, FOXE2, TITF2, TTF2 |
| Target/Specificity | FOXE1 belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. It functions as a thyroid transcription factor which likely plays a crucial role in thyroid morphogenesis. Mutations in this gene are associated with congenital hypothyroidism and cleft palate with thyroid dysgenesis. The map localization of this gene suggests it may also be a candidate gene for squamous cell epithelioma and hereditary sensory neuropathy type I.This intronless gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. This gene functions as a thyroid transcription factor which likely plays a crucial role in thyroid morphogenesis. Mutations in this gene are associated with congenital hypothyroidism and cleft palate with thyroid dysgenesis. The map localization of this gene suggests it may also be a candidate gene for squamous cell epithelioma and hereditary sensory neuropathy type I. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-FOXE1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | FOXE1 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FOXE1 |
|---|---|
| Synonyms | FKHL15, FOXE2, TITF2, TTF2 |
| Function | Transcription factor that binds consensus sites on a variety of gene promoters and activate their transcription. Involved in proper palate formation, most probably through the expression of MSX1 and TGFB3 genes which are direct targets of this transcription factor. Also implicated in thyroid gland morphogenesis. May indirectly play a role in cell growth and migration through the regulation of WNT5A expression. |
| Cellular Location | Nucleus. |
| Tissue Location | Detected in adult brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, heart, colon, small intestine testis and thymus. Expression was strongest in heart and pancreas |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This is a rabbit polyclonal antibody against FOXE1. It was validated on Western Blot using a cell lysate as a positive control. Abgent strives to provide antibodies covering each member of a whole protein family of your interest. We also use our best efforts to provide you antibodies recognize various epitopes of a target protein. For availability of antibody needed for your experiment, please inquire (sales@abgent.com).
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