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Cdk5r1 antibody - C-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | P61809 |
| Other Accession | NM_009871, NP_034001 |
| Reactivity | Human, Mouse, Rat, Dog, Horse, Bovine |
| Predicted | Human, Mouse, Pig, Dog, Guinea Pig |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 34031 Da |
| Gene ID | 12569 |
|---|---|
| Alias Symbol | Cdk5r, D11Bwg0379e, p25, p35 |
| Other Names | Cyclin-dependent kinase 5 activator 1, CDK5 activator 1, Cyclin-dependent kinase 5 regulatory subunit 1, TPKII regulatory subunit, Cyclin-dependent kinase 5 activator 1, p35, p35, Cyclin-dependent kinase 5 activator 1, p25, p25, Tau protein kinase II 23 kDa subunit, p23, Cdk5r1, Cdk5r, Nck5a |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Cdk5r1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Cdk5r1 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Cdk5r1 |
|---|---|
| Synonyms | Cdk5r, Nck5a |
| Function | p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-BMAL1 heterodimer in association with altered stability and subcellular distribution. |
| Cellular Location | [Cyclin-dependent kinase 5 activator 1, p35]: Cell membrane {ECO:0000250|UniProtKB:Q15078}; Lipid-anchor {ECO:0000250|UniProtKB:Q15078}; Cytoplasmic side {ECO:0000250|UniProtKB:Q15078}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q15078}. Note=In the primary cortical neurons, p35 is present in the peripheries and nerve terminals {ECO:0000250|UniProtKB:Q15078} |
| Tissue Location | Brain and neuron specific. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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