癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Kl antibody - N-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | O35082 |
| Other Accession | NM_013823, NP_038851 |
| Reactivity | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine |
| Predicted | Human, Mouse, Rat, Rabbit, Pig, Chicken, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 116398 Da |
| Gene ID | 16591 |
|---|---|
| Alias Symbol | alpha-kl |
| Other Names | Klotho, 3.2.1.31, Klotho peptide, Kl |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Kl antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Kl antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Kl |
|---|---|
| Function | Exhibits beta-glucuronidase activity in vitro despite lacking canonical catalytic Glu residues of glycosyl hydrolase 1 family enzymes (PubMed:14701853). Hydrolyzes steroid beta-D-glucuronides including estradiol-3-beta-D-glucuronide, estrone-3-beta-D-glucuronide and estriol-3-beta-D-glucuronide (PubMed:14701853). Essential for the interaction between FGF23 and FGFR1 and for FGF23-mediated regulation of renal vitamin D and phosphate homeostasis (PubMed:17086194). |
| Cellular Location | [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Apical cell membrane; Single-pass type I membrane protein. Note=Isoform 1 shedding leads to a soluble peptide. [Klotho peptide]: Secreted |
| Tissue Location | [Isoform 1]: Expressed in distal renal tubules, inner ear, ependymal cells of brain choroid plexus, elongating spermatids and mature oocytes (at protein level). Expressed in pituitary gland, ovary, brain, kidney, testis, pancreas and thyroid gland at levels more than tenfold higher than isoform 2 [Isoform 2]: Expressed in pituitary gland, ovary, brain, kidney, testis, pancreas and thyroid gland at levels more than tenfold lower than isoform 1. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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