MATR3 antibody - N-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application ![]()
| WB, IHC |
---|---|
Primary Accession | P43243 |
Other Accession | NM_018834, NP_061322 |
Reactivity | Human, Mouse, Rat, Rabbit, Pig, Dog, Horse, Bovine |
Predicted | Human, Mouse, Rat, Rabbit, Chicken, Bovine |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 94623 Da |
Gene ID | 9782 |
---|---|
Alias Symbol | MPD2, VCPDM |
Other Names | Matrin-3, MATR3, KIAA0723 |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 100 ul of distilled water. Final anti-MATR3 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | MATR3 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | MATR3 |
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Synonyms | KIAA0723 |
Function | May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233). |
Cellular Location | Nucleus matrix. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Beausoleil,S.A., (2004) Proc. Natl. Acad. Sci. U.S.A. 101 (33), 12130-12135Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.Publications:Valencia, C. A., Ju, W. & Liu, R. Matrin 3 is a Ca2+/calmodulin-binding protein cleaved by caspases. Biochem. Biophys. Res. Commun. 361, 281-6 (2007). WB, Human, Bovine, Rat, Dog, Pig, H, Rabbit, Guinea pig, Mouse17658460Kula, A. et al. Characterization of the HIV-1 RNA associated proteome identifies Matrin 3 as a nuclear cofactor of Rev function. Retrovirology 8, 60 (2011). WB, Human, Bovine, Rat, Dog, Pig, H, Rabbit, Guinea pig, Mouse21771346Kula, A., Gharu, L. & Marcello, A. HIV-1 pre-mRNA commitment to Rev mediated export through PSF and Matrin 3. Virology 435, 329-40 (2013). WB, Human, Bovine, Rat, Dog, Pig, H, Rabbit, Guinea pig, Mouse23158102

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