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MATR3 antibody - N-terminal region

Rabbit Polyclonal Antibody

     
  • 2 - MATR3 antibody - N-terminal region AI11817
    Rabbit Anti-MATR3 Antibody
    Paraffin Embedded Tissue: Human Heart
    Cellular Data: Myocardial cells
    Antibody Concentration: 4.0-8.0 μg/ml
    Magnification: 400X
  • 2 - MATR3 antibody - N-terminal region AI11817
    Rabbit Anti-MATR3 Antibody
    Paraffin Embedded Tissue: Human Muscle
    Cellular Data: Skeletal muscle cells
    Antibody Concentration: 4.0-8.0 μg/ml
    Magnification: 400X
  • 2 - MATR3 antibody - N-terminal region AI11817
    Rabbit Anti-MATR3 Antibody
    Paraffin Embedded Tissue: Human cardiac cell
    Cellular Data: Epithelial cells of renal tubule
    Antibody Concentration: 4.0-8.0 μg/ml
    Magnification: 400X
  • 1 - MATR3 antibody - N-terminal region AI11817

    WB Suggested Anti-MATR3 Antibody Titration: 1.25μg/ml
    Positive Control: Jurkat cell lysate
    MATR3 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC
Primary Accession P43243
Other Accession NM_018834, NP_061322
Reactivity Human, Mouse, Rat, Rabbit, Pig, Dog, Horse, Bovine
Predicted Human, Mouse, Rat, Rabbit, Chicken, Bovine
Host Rabbit
Clonality Polyclonal
Calculated MW 94623 Da
Additional Information
Gene ID 9782
Alias Symbol MPD2, VCPDM
Other Names Matrin-3, MATR3, KIAA0723
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 100 ul of distilled water. Final anti-MATR3 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsMATR3 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MATR3
Synonyms KIAA0723
Function May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233).
Cellular Location Nucleus matrix.
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

REFERENCES

Beausoleil,S.A., (2004) Proc. Natl. Acad. Sci. U.S.A. 101 (33), 12130-12135Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.Publications:Valencia, C. A., Ju, W. & Liu, R. Matrin 3 is a Ca2+/calmodulin-binding protein cleaved by caspases. Biochem. Biophys. Res. Commun. 361, 281-6 (2007). WB, Human, Bovine, Rat, Dog, Pig, H, Rabbit, Guinea pig, Mouse17658460Kula, A. et al. Characterization of the HIV-1 RNA associated proteome identifies Matrin 3 as a nuclear cofactor of Rev function. Retrovirology 8, 60 (2011). WB, Human, Bovine, Rat, Dog, Pig, H, Rabbit, Guinea pig, Mouse21771346Kula, A., Gharu, L. & Marcello, A. HIV-1 pre-mRNA commitment to Rev mediated export through PSF and Matrin 3. Virology 435, 329-40 (2013). WB, Human, Bovine, Rat, Dog, Pig, H, Rabbit, Guinea pig, Mouse23158102

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