癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TNRC6A antibody - N-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q8NDV7 |
| Other Accession | NM_014494, NP_055309 |
| Reactivity | Human, Mouse, Dog, Horse |
| Predicted | Mouse, Rat, Chicken, Dog, Horse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 210297 Da |
| Gene ID | 27327 |
|---|---|
| Alias Symbol | CAGH26, DKFZp666E117, FLJ22043, GW1, GW182, KIAA1460, MGC75384, TNRC6 |
| Other Names | Trinucleotide repeat-containing gene 6A protein, CAG repeat protein 26, EMSY interactor protein, GW182 autoantigen, Protein GW1, Glycine-tryptophan protein of 182 kDa, TNRC6A, CAGH26, KIAA1460, TNRC6 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-TNRC6A antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | TNRC6A antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | TNRC6A |
|---|---|
| Synonyms | CAGH26, KIAA1460, TNRC6 |
| Function | Plays a role in RNA-mediated gene silencing by both micro- RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA- dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes. |
| Cellular Location | Cytoplasm, P-body Note=Mammalian P-bodies are also known as GW bodies (GWBs) |
| Tissue Location | Ubiquitous. |
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Eulalio,A., (2008) Nat. Struct. Mol. Biol. 15 (4), 346-353 Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.Publications:Bukong, T. N., Hou, W., Kodys, K. & Szabo, G. Ethanol facilitates hepatitis C virus replication via up-regulation of GW182 and heat shock protein 90 in human hepatoma cells. Hepatology 57, 70-80 (2013). WB, H, Mouse, Human, Dog22898980
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