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>   首页   >   产品   >   一抗   >   精选抗体   >   斑马鱼抗体   >   MMP3 antibody - middle region   

MMP3 antibody - middle region

Rabbit Polyclonal Antibody

     
  • 2 - MMP3 antibody - middle region AI11969

    Application: IHC
    Species+tissue/cell type: Control-Human small intestine, Sample-human colorectal cancer
    Primary Antibody Dilution: 1:100
    Secondary Antibody: Biotinylated pig anti-rabbit+streptavidin-HRP
  • 1 - MMP3 antibody - middle region AI11969

    WB Suggested Anti-MMP3 Antibody Titration: 0.2-1 μg/ml
    ELISA Titer: 1:62500
    Positive Control: Hela cell lysate
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC
Primary Accession P28862
Other Accession NM_002422, NP_002413
Reactivity Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Dog, Horse, Bovine, Sheep
Predicted Human, Mouse, Rat, Rabbit, Pig, Dog, Horse
Host Rabbit
Clonality Polyclonal
Calculated MW 53845 Da
Additional Information
Gene ID 17392
Alias Symbol CHDS6, MGC126102, MGC126103, MGC126104, MMP-3, SL-1, STMY, STMY1, STR1
Other Names Stromelysin-1, SL-1, 3.4.24.17, EMS-2, Matrix metalloproteinase-3, MMP-3, Transin-1, Mmp3
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-MMP3 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsMMP3 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Mmp3
Function Metalloproteinase with a rather broad substrate specificity that can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates different molecules including growth factors, plasminogen or other matrix metalloproteinases such as MMP9. Once released into the extracellular matrix (ECM), the inactive pro-enzyme is activated by the plasmin cascade signaling pathway. Also acts intracellularly. For example, in dopaminergic neurons, gets activated by the serine protease HTRA2 upon stress and plays a pivotal role in DA neuronal degeneration by mediating microglial activation and alpha-synuclein/SNCA cleavage (PubMed:17116747). In addition, plays a role in immune response and possesses antiviral activity against various viruses (PubMed:35940311). Mechanistically, translocates from the cytoplasm into the cell nucleus upon virus infection to influence NF-kappa-B activities (PubMed:35940311).
Cellular Location Secreted, extracellular space, extracellular matrix
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

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