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RBBP6 antibody - N-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q7Z6E9 |
| Other Accession | NM_006910, NP_008841 |
| Reactivity | Human, Mouse, Rat, Rabbit, Pig, Dog, Bovine |
| Predicted | Human, Mouse, Rat, Rabbit, Pig, Dog, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 201564 Da |
| Gene ID | 5930 |
|---|---|
| Alias Symbol | DKFZp686P0638, DKFZp761B2423, MY038, P2P-R, RBQ-1, PACT, SNAMA |
| Other Names | E3 ubiquitin-protein ligase RBBP6, 6.3.2.-, Proliferation potential-related protein, Protein P2P-R, Retinoblastoma-binding Q protein 1, RBQ-1, Retinoblastoma-binding protein 6, p53-associated cellular protein of testis, RBBP6, P2PR, PACT, RBQ1 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-RBBP6 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | RBBP6 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RBBP6 |
|---|---|
| Synonyms | P2PR, PACT, RBQ1 |
| Function | E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). |
| Cellular Location | Nucleus, nucleolus. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Colocalizes with mitotic chromosomes. Colocalizes with NEK6 in the centrosome |
| Tissue Location | Highly expressed in the placenta and testis. Expressed at lower levels in the brain, heart, kidney, liver and lung Overexpressed in esophageal cancer. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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