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Tmem106b antibody - C-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q80X71 |
| Other Accession | NM_027992, NP_082268 |
| Reactivity | Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Dog, Guinea Pig, Horse, Bovine |
| Predicted | Human, Mouse, Chicken, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 31172 Da |
| Gene ID | 71900 |
|---|---|
| Alias Symbol | 2310036D22Rik, 5830455K21Rik, 6430519M21Rik, AI428776, AI661344 |
| Other Names | Transmembrane protein 106B, Tmem106b |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Tmem106b antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Tmem106b antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Tmem106b |
|---|---|
| Function | In neurons, involved in the transport of late endosomes/lysosomes (PubMed:25066864, PubMed:32160553). May be involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking (PubMed:25066864). May act as a molecular brake for retrograde transport of late endosomes/lysosomes, possibly via its interaction with MAP6 (By similarity). In motoneurons, may mediate the axonal transport of lysosomes and axonal sorting at the initial segment (PubMed:32160553). It remains unclear whether TMEM106B affects the transport of moving lysosomes in the anterograde or retrograde direction in neurites and whether it is particularly important in the sorting of lysosomes in axons or in dendrites (Probable). In neurons, may also play a role in the regulation of lysosomal size and responsiveness to stress (PubMed:25066864). Required for proper lysosomal acidification (PubMed:28728022). |
| Cellular Location | Late endosome membrane; Single-pass type II membrane protein. Lysosome membrane; Single-pass type II membrane protein. Cell membrane {ECO:0000250|UniProtKB:Q9NUM4}; Single-pass type II membrane protein. Note=Colocalizes with LAMP1. A small fraction resides on the cell surface (By similarity). {ECO:0000250|UniProtKB:Q9NUM4, ECO:0000269|PubMed:23136129, ECO:0000269|PubMed:25066864} |
| Tissue Location | Expressed in the brain, in neurons (at protein level) (PubMed:25066864, PubMed:28728022, PubMed:29855382, PubMed:32160553, PubMed:32761777). Expressed in the spinal cord (at protein level) (PubMed:32160553). |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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