癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Nbr1 antibody - C-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | P97432 |
| Other Accession | NM_008676, NP_032702 |
| Reactivity | Human, Mouse, Rat, Rabbit, Pig, Dog, Horse, Bovine |
| Predicted | Human, Mouse, Rat, Rabbit, Dog, Horse, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 109958 Da |
| Gene ID | 17966 |
|---|---|
| Alias Symbol | mKIAA0049 |
| Other Names | Next to BRCA1 gene 1 protein, Membrane component chromosome 17 surface marker 2 homolog, Neighbor of BRCA1 gene 1 protein, Nbr1, M17s2 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Nbr1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Nbr1 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Nbr1 |
|---|---|
| Synonyms | M17s2 |
| Function | Ubiquitin-binding autophagy adapter that participates in different processes including host defense or intracellular homeostasis (PubMed:31916398, PubMed:34374750). Possesses a double function during the selective autophagy by acting as a shuttle bringing ubiquitinated proteins to autophagosomes and also by participating in the formation of protein aggregates. Plays a role in the regulation of the innate immune response by modulating type I interferon production and targeting ubiquitinated IRF3 for autophagic degradation (By similarity). In response to oxidative stress, promotes an increase in SQSTM1 levels, phosphorylation, and body formation by preventing its autophagic degradation (PubMed:31916398). In turn, activates the KEAP1- NRF2/NFE2L2 antioxidant pathway (PubMed:31916398). Also plays non- autophagy role by mediating the shuttle of IL-12 to late endosome for subsequent secretion (PubMed:34374750). |
| Cellular Location | Cytoplasm. Cytoplasmic vesicle, autophagosome {ECO:0000250|UniProtKB:Q14596} Lysosome {ECO:0000250|UniProtKB:Q14596}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000250|UniProtKB:Q501R9}. Note=In cardiac muscles localizes to the sarcomeric M line (By similarity). Is targeted to lysosomes for degradation (By similarity) {ECO:0000250|UniProtKB:Q14596, ECO:0000250|UniProtKB:Q501R9, ECO:0000269|PubMed:31916398} |
| Tissue Location | Expressed in brain. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Chambers J.A.,et al.Genomics 38:305-313(1996).
Dimitrov S.,et al.Gene 262:89-98(2001).
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