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MTMR12 antibody - middle region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q9C0I1 |
| Other Accession | NM_001040446, NP_001035536 |
| Reactivity | Human, Mouse, Rat, Rabbit, Dog, Guinea Pig, Horse, Bovine |
| Predicted | Rabbit, Pig, Dog, Guinea Pig, Horse, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 86148 Da |
| Gene ID | 54545 |
|---|---|
| Alias Symbol | 3-PAP, PIP3AP |
| Other Names | Myotubularin-related protein 12, Phosphatidylinositol 3 phosphate 3-phosphatase adapter subunit, 3-PAP, 3-phosphatase adapter protein, MTMR12, KIAA1682, PIP3AP |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-MTMR12 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | MTMR12 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MTMR12 |
|---|---|
| Synonyms | KIAA1682, PIP3AP |
| Function | Acts as an adapter for the myotubularin-related phosphatases (PubMed:11504939, PubMed:12847286, PubMed:23818870). Regulates phosphatase MTM1 protein stability and possibly its intracellular location (PubMed:23818870). By stabilizing MTM1 protein levels, required for skeletal muscle maintenance but not for myogenesis (By similarity). |
| Cellular Location | Cytoplasm. Sarcoplasmic reticulum {ECO:0000250|UniProtKB:Q80TA6}. Cytoplasm, myofibril, sarcomere {ECO:0000250|UniProtKB:Q80TA6}. Note=Localizes to punctate vesicles when associated with MTM1 (PubMed:12847286) Localizes to triads, a structure formed by a T tubule and two sarcoplasmic reticulum terminal cisterna (By similarity). In skeletal muscles, co-localizes with MTM1 in the sarcomere (By similarity) Partially localizes to the sarcoplasmic reticulum in skeletal muscles (By similarity). {ECO:0000250|UniProtKB:Q80TA6, ECO:0000269|PubMed:12847286} |
| Tissue Location | Expressed in skeletal muscles (at protein level) (PubMed:23818870). Ubiquitous with prominent expression in brain, heart, kidney, placenta, and lung (PubMed:11504939) |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Nandurkar H.H.,et al.Proc. Natl. Acad. Sci. U.S.A. 98:9499-9504(2001).
Nagase T.,et al.DNA Res. 7:347-355(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Nandurkar H.H.,et al.Proc. Natl. Acad. Sci. U.S.A. 100:8660-8665(2003).
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