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Eif2c3 antibody - N-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q8CJF9 |
| Other Accession | NM_153402, NP_700451 |
| Reactivity | Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Dog, Guinea Pig, Horse, Bovine |
| Predicted | Human, Mouse, Rat, Rabbit, Pig, Chicken, Dog, Horse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 97277 Da |
| Gene ID | 214150 |
|---|---|
| Alias Symbol | AW048688, Ago3, C130014L07Rik, Eif2c3 |
| Other Names | Protein argonaute-3 {ECO:0000255|HAMAP-Rule:MF_03032}, Argonaute3 {ECO:0000255|HAMAP-Rule:MF_03032}, mAgo3, Argonaute RISC catalytic component 3, Eukaryotic translation initiation factor 2C 3 {ECO:0000255|HAMAP-Rule:MF_03032}, eIF-2C 3 {ECO:0000255|HAMAP-Rule:MF_03032}, eIF2C 3 {ECO:0000255|HAMAP-Rule:MF_03032}, Piwi/argonaute family protein meIF2C3, Ago3, Eif2c3 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Eif2c3 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Eif2c3 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Ago3 |
|---|---|
| Synonyms | Eif2c3 |
| Function | Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Proposed to be involved in stabilization of small RNA derivates (siRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent siRNA- dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4 (PubMed:19174539). Possesses RNA slicer activity but only on select RNAs bearing 5'- and 3'-flanking sequences to the region of guide- target complementarity (By similarity). |
| Cellular Location | Cytoplasm, P-body {ECO:0000255|HAMAP- Rule:MF_03032} |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Doi N.,et al.Curr. Biol. 13:41-46(2003).
Carninci P.,et al.Science 309:1559-1563(2005).
Church D.M.,et al.PLoS Biol. 7:E1000112-E1000112(2009).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Su H.,et al.Genes Dev. 23:304-317(2009).
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