癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SERPINB6 antibody - middle region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | P35237 |
| Other Accession | NM_004568, NP_004559 |
| Reactivity | Human, Bovine |
| Predicted | Human, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 42622 Da |
| Gene ID | 5269 |
|---|---|
| Alias Symbol | CAP, DKFZp686I04222, MGC111370, MSTP057, PI6, PTI, SPI3, DFNB91 |
| Other Names | Serpin B6, Cytoplasmic antiproteinase, CAP, Peptidase inhibitor 6, PI-6, Placental thrombin inhibitor, SERPINB6, PI6, PTI |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-SERPINB6 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | SERPINB6 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SERPINB6 |
|---|---|
| Synonyms | PI6, PTI |
| Function | May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood (By similarity). Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss. |
| Cellular Location | Cytoplasm |
| Tissue Location | Expressed in keratinocytes (at protein level). Highest levels in skeletal muscle. Also found in placenta, cardiac muscle, lung, liver, kidney and pancreas. Expressed in the inner ear hair cells. Expressed abundantly by normal mast cells in different tissues and by mast cells in mastocytoma lesions |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Coughlin P.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:9417-9421(1993).
Morgenstern K.A.,et al.Biochemistry 33:3432-3441(1994).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Mungall A.J.,et al.Nature 425:805-811(2003).
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