癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Arhgef4 Antibody - N-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q7TNR9 |
| Other Accession | NM_183019, NP_898840 |
| Reactivity | Human, Mouse, Rat, Rabbit, Dog, Guinea Pig, Horse, Bovine |
| Predicted | Human, Mouse, Rat, Rabbit, Pig, Dog, Guinea Pig, Horse, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 56679 Da |
| Gene ID | 226970 |
|---|---|
| Alias Symbol | 9330140K16Rik, Asef, ENSMUSG00000070955 |
| Other Names | Rho guanine nucleotide exchange factor 4, APC-stimulated guanine nucleotide exchange factor, Asef, Arhgef4, Kiaa1112 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Arhgef4 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Arhgef4 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Arhgef4 |
|---|---|
| Synonyms | Kiaa1112 |
| Function | Acts as a guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion (By similarity). Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. |
| Cellular Location | Cytoplasm. Note=Colocalized with APC in the synapse of olfactory glomerulus |
| Tissue Location | Expressed in colon epithelial cells. Highly expressed in CNS, including hippocampus, olfactory bulb and cerebellum Expression is aberrantly enhanced in most colorectal tumors |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Church D.M.,et al.PLoS Biol. 7:E1000112-E1000112(2009).
Okazaki N.,et al.DNA Res. 10:35-48(2003).
Okazaki N.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Kawasaki Y.,et al.Science 289:1194-1197(2000).
Kawasaki Y.,et al.EMBO Rep. 10:1355-1362(2009).
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