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Ubxn6 antibody - middle region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q99PL6 |
| Other Accession | NM_024432, NP_077752 |
| Reactivity | Human, Mouse, Rat, Zebrafish, Pig, Dog, Guinea Pig, Horse, Bovine, Yeast |
| Predicted | Human, Mouse, Zebrafish, Chicken, Dog, Guinea Pig, Horse, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 49796 Da |
| Gene ID | 66530 |
|---|---|
| Alias Symbol | 1200008L11Rik, 2210415J11Rik, AU040909, Ubxd1, Ubxdc2 |
| Other Names | UBX domain-containing protein 6, UBX domain-containing protein 1, Ubxn6, Ubxd1, Ubxdc2 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Ubxn6 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Ubxn6 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Ubxn6 {ECO:0000312|MGI:MGI:1913780} |
|---|---|
| Function | May negatively regulate the ATPase activity of VCP, an ATP- driven segregase that associates with different cofactors to control a wide variety of cellular processes. As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation. It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q9BZV1}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9BZV1}. Membrane {ECO:0000250|UniProtKB:Q9BZV1}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9BZV1}. Nucleus {ECO:0000250|UniProtKB:Q9BZV1} Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9BZV1}. Early endosome membrane {ECO:0000250|UniProtKB:Q9BZV1}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9BZV1}. Late endosome membrane {ECO:0000250|UniProtKB:Q9BZV1}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9BZV1}. Lysosome membrane {ECO:0000250|UniProtKB:Q9BZV1}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9BZV1}. Note=Localizes at the centrosome both in interphase and during mitosis. May be recruited to endosomal and lysosomal membranes as part of a ternary complex with CAV1 and VCP Recruited to damaged lysosomes decorated with K48-linked ubiquitin chains. {ECO:0000250|UniProtKB:Q9BZV1} |
| Tissue Location | Widely expressed (at protein level). Highest expression in brain (at protein level). |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Carim-Todd L.,et al.Biochim. Biophys. Acta 1517:298-301(2001).
Carninci P.,et al.Science 309:1559-1563(2005).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Church D.M.,et al.PLoS Biol. 7:E1000112-E1000112(2009).
Madsen L.,et al.Int. J. Biochem. Cell Biol. 40:2927-2942(2008).
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