癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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DHRS4 antibody - N-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q9BTZ2 |
| Other Accession | NM_021004, NP_066284 |
| Reactivity | Human, Mouse, Rat, Rabbit, Zebrafish, Dog, Guinea Pig, Horse, Bovine |
| Predicted | Human, Mouse, Rat, Rabbit, Pig, Dog, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 29537 Da |
| Gene ID | 10901 |
|---|---|
| Alias Symbol | FLJ11008, NRDR, SCAD-SRL, SDR-SRL, SDR25C1 |
| Other Names | Dehydrogenase/reductase SDR family member 4, 1.1.1.184, NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase, CR, PHCR, NADPH-dependent retinol dehydrogenase/reductase, NRDR, humNRDR, Peroxisomal short-chain alcohol dehydrogenase, PSCD, SCAD-SRL, Short-chain dehydrogenase/reductase family member 4, DHRS4 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-DHRS4 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | DHRS4 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | DHRS4 (HGNC:16985) |
|---|---|
| Function | NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including ketosteroids, alpha-dicarbonyl compounds, aldehydes, aromatic ketones and quinones (PubMed:18571493, PubMed:19056333). Reduces 3-ketosteroids and benzil into 3beta-hydroxysteroids and R-benzoin, respectively, in contrast to the stereoselectivity of non-primate DHRS4s which produce 3alpha-hydroxysteroids and S-benzoin (PubMed:19056333). Displays low activity toward all-trans-retinal and no activity toward 9-cis-retinal as compared to non-primate mammals (PubMed:18571493, PubMed:19056333). In the reverse reaction, catalyze the NAD-dependent oxidation of 3beta- hydroxysteroids and alcohol, but with much lower efficiency (PubMed:18571493, PubMed:19056333). Involved in the metabolism of 3beta-hydroxysteroids, isatin and xenobiotic carbonyl compounds (PubMed:18571493, PubMed:19056333). |
| Cellular Location | [Isoform 1]: Peroxisome Note=Isoform 4 is not peroxisomal. |
| Tissue Location | [Isoform 1]: Predominantly expressed in normal cervix (at protein level). [Isoform 5]: Expressed in a few neoplastic cervical tissues. [Isoform 8]: High expression in liver. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Fransen M.,et al.Biochem. J. 340:561-568(1999).
Furukawa A.,et al.Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
Du J.,et al.Yi Chuan Xue Bao 31:661-667(2004).
Tu Q.,et al.Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
Li Y.F.,et al.Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
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