癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
IFI30 Antibody - middle region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | P13284 |
| Other Accession | NM_006332, NP_006323 |
| Reactivity | Human, Mouse, Rat, Pig, Dog, Horse, Bovine, Sheep |
| Predicted | Human, Mouse, Rat, Pig, Dog, Horse, Bovine, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 27964 Da |
| Gene ID | 10437 |
|---|---|
| Alias Symbol | GILT, IFI-30, IP30, MGC32056 |
| Other Names | Gamma-interferon-inducible lysosomal thiol reductase, 1.8.-.-, Gamma-interferon-inducible protein IP-30, Legumaturain, IFI30, GILT, IP30 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-IFI30 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | IFI30 Antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | IFI30 (HGNC:5398) |
|---|---|
| Function | Lysosomal thiol reductase that catalyzes protein disulfide bonds reduction (PubMed:10639150). Plays an important role in antigen processing and presentation, of namely both major histocompatibility complex (MHC) class I- and class II-restricted antigen by reducing the disulfide bonds of endocytosed proteins and facilitating their unfolding and optimal degradation (PubMed:10639150). Shares with thioredoxin a reduction mechanism in which the N-terminal cysteine thiol group in the CXXC active site motif initiates a nucleophilic attack on the substrate disulfide bond,resulting in the formation of a mixed disulfide-linked enzyme-substrate intermediate (Probable). Subsequent intramolecular attack by the second cysteine thiol group enables the release of the reduced substrate and oxidized enzyme (Probable). Lysosomal cysteine is a physiological reducing agent that is capable of reducing IFI30, so that it can catalyzes the next reaction (PubMed:10852914). Dithiothreitol, cysteine, and cysteinyl glycine, but not glutathione, are capable of regenerating active precursor and mature IFI30 in vitro (PubMed:10639150, PubMed:10852914). |
| Cellular Location | Secreted. Lysosome. Note=A small amount of the precursor can be secreted outside the cell as a dimer |
| Tissue Location | Expressed constitutively in antigen-presenting cells. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Luster A.D.,et al.J. Biol. Chem. 263:12036-12043(1988).
Arunachalam B.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:745-750(2000).
Arahira M.,et al.Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Grimwood J.,et al.Nature 428:529-535(2004).
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