癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
STK19 Antibody - middle region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | P49842 |
| Other Accession | NM_032454, NP_115830 |
| Reactivity | Human, Mouse, Rat, Pig, Guinea Pig, Horse, Bovine |
| Predicted | Human, Mouse, Rat, Pig, Guinea Pig, Horse, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 28465 Da |
| Gene ID | 8859 |
|---|---|
| Alias Symbol | D6S60, D6S60E, G11, HLA-RP1, MGC117388, RP1 |
| Other Names | Serine/threonine-protein kinase 19, 2.7.11.1, Protein G11, Protein RP1, STK19, G11, RP1 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-STK19 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | STK19 Antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | WHR1 (HGNC:11398) |
|---|---|
| Function | DNA-binding protein which is required for efficient transcription-coupled nucleotide excision repair (TC-NER) (PubMed:38252411, PubMed:38890355, PubMed:39353615, PubMed:39547223, PubMed:39547228, PubMed:39547229). Acts as part of a TC-NER complex which assembles and interacts with RNA polymerase II (RNAPII) when it stalls at DNA lesions (PubMed:39547223, PubMed:39547228, PubMed:39547229). TC-NER complex subunit UVSSA binds to the GTF2H1/p62 subunit of the TFIIH transcription factor complex, tethering TFIIH to the TC-NER complex (PubMed:39547228). WHR1/STK19 then interacts with the XPD helicase subunit of TFIIH which guides TFIIH to DNA downstream of the stalled RNAPII, ensuring DNA repair (PubMed:39353615, PubMed:39547228, PubMed:39547229). Directly interacts with RNAPII and also binds to downstream DNA (PubMed:39547229). Promotes the timely removal of DNA damage-stalled RNAPII, allowing downstream NER factors to access DNA lesions (PubMed:39547228, PubMed:39547229). Required for monoubiquitination of UVSSA (PubMed:39353615). Regulates repositioning and stabilization of UVSSA within the TC-NER complex (PubMed:39547223). Stimulates ubiquitination of RNAPII complex member RBP1 (PubMed:39547223). Also binds to RNA and regulates the expression levels of many mRNAs (PubMed:38252411, PubMed:38890355). |
| Cellular Location | [Isoform 4]: Nucleus [Isoform 1]: Nucleus. Cytoplasm |
| Tissue Location | Monocytes, hepatocytes, epithelial cells, T- and B- lymphocytes. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Sargent C.A.,et al.Hum. Mol. Genet. 3:481-488(1994).
Liming S.,et al.J. Biol. Chem. 269:8466-8476(1994).
Xie T.,et al.Genome Res. 13:2621-2636(2003).
Mungall A.J.,et al.Nature 425:805-811(2003).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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