癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
STK19 Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P49842 |
| Other Accession | Q5ST75 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 28465 Da |
| Antigen Region | 278-308 aa |
| Gene ID | 8859 |
|---|---|
| Other Names | Serine/threonine-protein kinase 19, Protein G11, Protein RP1, STK19, G11, RP1 |
| Target/Specificity | This STK19 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 278-308 amino acids from the C-terminal region of human STK19. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | STK19 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | WHR1 (HGNC:11398) |
|---|---|
| Function | DNA-binding protein which is required for efficient transcription-coupled nucleotide excision repair (TC-NER) (PubMed:38252411, PubMed:38890355, PubMed:39353615, PubMed:39547223, PubMed:39547228, PubMed:39547229). Acts as part of a TC-NER complex which assembles and interacts with RNA polymerase II (RNAPII) when it stalls at DNA lesions (PubMed:39547223, PubMed:39547228, PubMed:39547229). TC-NER complex subunit UVSSA binds to the GTF2H1/p62 subunit of the TFIIH transcription factor complex, tethering TFIIH to the TC-NER complex (PubMed:39547228). WHR1/STK19 then interacts with the XPD helicase subunit of TFIIH which guides TFIIH to DNA downstream of the stalled RNAPII, ensuring DNA repair (PubMed:39353615, PubMed:39547228, PubMed:39547229). Directly interacts with RNAPII and also binds to downstream DNA (PubMed:39547229). Promotes the timely removal of DNA damage-stalled RNAPII, allowing downstream NER factors to access DNA lesions (PubMed:39547228, PubMed:39547229). Required for monoubiquitination of UVSSA (PubMed:39353615). Regulates repositioning and stabilization of UVSSA within the TC-NER complex (PubMed:39547223). Stimulates ubiquitination of RNAPII complex member RBP1 (PubMed:39547223). Also binds to RNA and regulates the expression levels of many mRNAs (PubMed:38252411, PubMed:38890355). |
| Cellular Location | [Isoform 4]: Nucleus [Isoform 1]: Nucleus. Cytoplasm |
| Tissue Location | Monocytes, hepatocytes, epithelial cells, T- and B- lymphocytes. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
SSTK19 is a serine/threonine kinase which localizes predominantly to the nucleus. Its specific function is unknown; it is possible that phosphorylation of this protein is involved in transcriptional regulation.
REFERENCES
Gomez-Escobar, N., et al., J. Biol. Chem. 273(47):30954-30960 (1998).
Yang, Z., et al., Genomics 53(3):338-347 (1998).
Ulgiati, D., et al., Immunogenetics 43(4):250-252 (1996).
Sargent, C.A., et al., Hum. Mol. Genet. 3(3):481-488 (1994).
Shen, L., et al., J. Biol. Chem. 269(11):8466-8476 (1994).
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