癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
RRP8 Antibody - N-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | O43159 |
| Other Accession | NM_015324, NP_056139 |
| Reactivity | Human, Rat, Rabbit, Dog, Guinea Pig, Horse, Bovine, Yeast |
| Predicted | Human, Rat, Rabbit, Pig, Dog, Guinea Pig, Horse, Bovine, Yeast |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 50715 Da |
| Gene ID | 23378 |
|---|---|
| Alias Symbol | KIAA0409 |
| Other Names | Ribosomal RNA-processing protein 8, 2.1.1.-, Cerebral protein 1, Nucleomethylin, RRP8, KIAA0409, NML |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-RRP8 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | RRP8 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | RRP8 |
|---|---|
| Synonyms | KIAA0409, NML |
| Function | Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown. |
| Cellular Location | Nucleus, nucleolus Note=Localizes at rDNA locus |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Yazaki M.,et al.Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases.
Ishikawa K.,et al.DNA Res. 4:307-313(1997).
Scherl A.,et al.Mol. Biol. Cell 13:4100-4109(2002).
Andersen J.S.,et al.Curr. Biol. 12:1-11(2002).
Olsen J.V.,et al.Cell 127:635-648(2006).
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