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>   首页   >   产品   >   一抗   >   癌症   >   SERPINA1 antibody - C-terminal region   

SERPINA1 antibody - C-terminal region

Rabbit Polyclonal Antibody

     
  • 2 - SERPINA1 antibody - C-terminal region AI16165

    WB Suggested Anti-SERPINA1 Antibody Titration: 4.0-8.0
    Positive Control: Human kidney lysate
  • 1 - SERPINA1 antibody - C-terminal region AI16165

    WB Suggested Anti-SERPINA1 Antibody Titration: 1.25μg/ml
    ELISA Titer: 1:12500
    Positive Control: HepG2 cell lysate
    SERPINA1 is strongly supported by BioGPS gene expression data to be expressed in Human HepG2 cells
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC
Primary Accession P01009
Other Accession NM_000295, NP_000286
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 46737 Da
Additional Information
Gene ID 5265
Alias Symbol PI, A1A, AAT, PI1, A1AT, PRO2275, alpha1AT
Other Names Alpha-1-antitrypsin, Alpha-1 protease inhibitor, Alpha-1-antiproteinase, Serpin A1, Short peptide from AAT, SPAAT, SERPINA1, AAT, PI
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 100 ul of distilled water. Final anti-SERPINA1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsSERPINA1 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SERPINA1 (HGNC:8941)
Synonyms AAT, PI
Function Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.
Cellular Location Secreted. Endoplasmic reticulum. Note=The S and Z allele are not secreted effectively and accumulate intracellularly in the endoplasmic reticulum
Tissue Location Ubiquitous. Expressed in leukocytes and plasma.
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.

REFERENCES

Bollen A.,et al.DNA 2:255-264(1983).
Long G.L.,et al.Biochemistry 23:4828-4837(1984).
Rosenberg S.,et al.Nature 312:77-80(1984).
Ciliberto G.,et al.Cell 41:531-540(1985).
Nukiwa T.,et al.J. Biol. Chem. 261:15989-15994(1986).

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