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DOK2 antibody - C-terminal region
Rabbit Polyclonal Antibody
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- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | O60496 |
| Other Accession | NM_003974, NP_003965 |
| Reactivity | Human, Mouse, Rat, Pig, Dog, Horse, Bovine |
| Predicted | Human, Mouse, Rat, Pig, Dog, Horse, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 45379 Da |
| Gene ID | 9046 |
|---|---|
| Alias Symbol | p56DOK, p56dok-2 |
| Other Names | Docking protein 2, Downstream of tyrosine kinase 2, p56(dok-2), DOK2 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-DOK2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | DOK2 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DOK2 |
|---|---|
| Function | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity). |
| Tissue Location | Highly expressed in peripheral blood leukocytes, lymph nodes and spleen. Lower expression in thymus, bone marrow and fetal liver. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity).
REFERENCES
Di Cristofano A.,et al.J. Biol. Chem. 273:4827-4830(1998).
Brill L.M.,et al.Anal. Chem. 76:2763-2772(2004).
Rush J.,et al.Nat. Biotechnol. 23:94-101(2005).
Mayya V.,et al.Sci. Signal. 2:RA46-RA46(2009).
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