Anti-SLC25A11 Antibody (Internal)

Rabbit Anti Human Polyclonal Antibody

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB, IHC-P
Primary Accession	Q02978
Predicted	Human, Mouse, Rat, Monkey
Host	Rabbit
Clonality	Polyclonal
Calculated MW	34062 Da
Concentration (mg/ml)	1 mg/ml

Additional Information
Gene ID	8402
Alias Symbol	SLC25A11
Other Names	SLC25A11, OGC, SLC20A4, OGCP, Oxoglutarate carrier, Oxoglutarate translocator, Oxoglutarate/malate carrier
Target/Specificity	Recognizes endogenous levels of SLC25A11 protein.
Reconstitution & Storage	PBS, pH 7.3, 0.01% sodium azide, 30% glycerol. Store at -20°C. Aliquot to avoid freeze/thaw cycles.
Precautions	Anti-SLC25A11 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.

Protein Information
Name	SLC25A11
Synonyms	SLC20A4
Function	Catalyzes the transport of 2-oxoglutarate (alpha- oxoglutarate) across the inner mitochondrial membrane in an electroneutral exchange for malate (PubMed:25637873, PubMed:38937634). Can also exchange 2-oxoglutarate for other dicarboxylic acids such as malonate, succinate, maleate and oxaloacetate, although with lower affinity (By similarity). Substrate exchange across the membrane occurs consecutively with one substrate being transported first, then dissociating from the substrate binding site before the second substrate binds for transport in the opposite direction (PubMed:38937634). Does not transport glutathione (PubMed:25637873). Contributes to several metabolic processes, including the malate- aspartate shuttle, the oxoglutarate/isocitrate shuttle, gluconeogenesis from lactate, and nitrogen metabolism (By similarity). Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae (PubMed:21448454). Involved in the regulation of apoptosis (By similarity).
Cellular Location	Mitochondrion inner membrane {ECO:0000250\|UniProtKB:P97700}; Multi-pass membrane protein
Tissue Location	Most highly expressed in the heart.