癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-CACNA1E / Cav2.3 Antibody (Internal)
Rabbit Anti Human Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | Q15878 |
| Predicted | Human, Mouse, Rat, Rabbit |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 261731 Da |
| Concentration (mg/ml) | 1 mg/ml |
| Gene ID | 777 |
|---|---|
| Alias Symbol | CACNA1E |
| Other Names | CACNA1E, BII, Brain calcium channel II, Cav2.3, CACNL1A6, Alpha 1e, CACH6, Cchra1 |
| Target/Specificity | Recognizes endogenous levels of Cav2.3 protein. |
| Reconstitution & Storage | PBS, pH 7.3, 0.01% sodium azide, 30% glycerol. Store at -20°C. Aliquot to avoid freeze/thaw cycles. |
| Precautions | Anti-CACNA1E / Cav2.3 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CACNA1E |
|---|---|
| Synonyms | CACH6, CACNL1A6 |
| Function | Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells (PubMed:30343943). They are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel. They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing. |
| Cellular Location | Membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in neuronal tissues and in kidney. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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